Results 41 to 50 of about 6,511,310 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Green analytical chemistry-a new Elsevier's journal facing the realities of modern analytical chemistry and more sustainable future [PDF]

, 2022
Nowadays, all sciences, including chemistry and chemical engineering, are developing very dynamically. This can be seen in the rapidly growing number of scientific publications and citations in almost every field. Analytical chemistry is no exception and
Arduini, Fabiana, Zheng Ouyang, Renata Wietecha-Posłuszny, Pawliszyn, Janusz, Nowak, Paweł Mateusz, Mondello, Luigi, Ouyang, Zheng, Paweł Mateusz Nowak, Wietecha-Posłuszny, Renata, Nowak, Paweł, Barceló, Damià, Fabiana Arduini, Damià Barceló, Luigi Mondello, Janusz Pawliszyn   +14 more
core   +1 more source

Sustainable Ethanol‐Based Reversed‐Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics

ChemistryOpen
This study presents a sustainable chromatographic method for the analysis of diltiazem. Retention behavior and the effect of mobile phase pH were investigated to determine the dissociation constant. Chromatographic experiments were performed at 37°C on a
Zehra Üstün, İlkay Konçe, Ebru Çubuk Demiralay   +2 more
doaj   +1 more source

Uncorking white wine liking: Combining analytical chemistry and chemometrics with crowd-sourced data to predict quality ratings [PDF]

Food Chemistry
Quality perception is a crucial aspect of wine research, particularly regarding consumer acceptance and quality impression. These assessments are challenging because consumers frequently incorporate extrinsic cues when evaluating hedonic quality. A unique perspective on wine quality is provided by the platform Vivino, which utilizes crowd-sourced ...
Hjertholm, Frederikke, Goetz, Rabea, Schneide, Paul Albert Anselm, Petersen, Mikael Agerlin, Bro, Rasmus, Quintanilla-Casas, Beatriz   +5 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Greenness of procedures using NADES in the preparation of vegetal samples: Comparison of five green metrics

Talanta Open, 2022
The principles of green analytical chemistry have led to the development of analytical procedures that are increasingly sustainable. Different metrics have been created for the evaluation of greenness, although determination of the green nature of new ...
Sabrina S. Ferreira, Thomas A. Brito, Ana P.R. Santana, Taciana G.S. Guimarães, Rafaela S. Lamarca, Karen C. Ferreira, Paulo C. F. Lima Gomes, Andrea Oliveira, Clarice D.B. Amaral, Mario H. Gonzalez   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

European analytical column No. 36 (January 2008)

, 2008
The annual European Analytical Column informs the members of the European Association for Chemical and Molecular Sciences as well as the readers of prestigious international journals on analytical chemistry about current developments of this scientific ...
ANDERSON J.E.T., Andersen, Jens Enevold Thaulov, Emons, H., Karlberg, Bo,, Andersen, Jens E. T., Emons, Hendrik, KARLBERG B., Andersen, J. E. T., EMONS Hendrik, Karlberg, Bo, Karlberg, B.   +10 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source