Results 51 to 60 of about 6,511,310 (294)

European Analytical Column:Analytical chemistry faces challenges

, 2009
The European Analytical Column has once more invited a guest columnist to give his views on various matters related to analytical chemistry in Europe.
Andersen, Jens Enevold Thaulov, Karlberg, Bo,, Andersen, Jens E.T., Grasserbauer, M., Andersen, Jens E. T., Karlberg, Bo, Karlberg, B., Grasserbauer, Manfred   +7 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

TriCA as a Triple-Color Assessment Tool for Analytical Methods

Analytica
The evaluation of analytical methods has evolved beyond traditional validation parameters to encompass environmental sustainability, analytical reliability, and practical applicability.
Fotouh R. Mansour, Khalid M. Omer, Sameera Sh. Mohammed Ameen, Marcello Locatelli, Imran Ali, Alaa Bedair   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Green TLC-densitometric method for determination of cytarabine and granisetron in spiked human plasma: optimization and whiteness assessment

BMC Chemistry
Cytarabine (CYT) is a cornerstone in the treatment of acute myeloid leukemia (AML) and is often co-administered with granisetron (GRS) to manage chemotherapy-induced nausea and vomiting (CINV).
Salwa I. Tohamy, Eglal A. Abdelaleem, Adel Lashien, Mahmoud M. Amin, Nessreen S. Abdelhamid   +4 more
doaj   +1 more source

A prospective evaluation of microscale thermophoresis coupled with mass spectrometry using the “RGB_ex-ante” model

Green Analytical Chemistry
The evaluation of greenness and whiteness is usually made retrospectively (ex-post) – for a developed and validated methodology ready for use. However, it can also be made ex-ante, i.e.
Paweł Mateusz Nowak, Aleksandra Zima, Małgorzata Gołąb, Michał Woźniakiewicz   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Integrated sustainability and risk assessment of spectrophotometric methods for determining a veterinary drug combination

Scientific Reports
Effective, sustainable, and white spectrophotometric methods were developed for the analytical assessment of both rafoxanide (RAF) and Levamisole HCl (LEV). Both components were resolved by constant multiplication coupled with spectrum subtraction (CM-SS)
Mahmoud G. Hagag, Ahmed H. Nadim, Maha Kamal, Samah S. Abbas, Nesma M. Fahmy   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source