Results 71 to 80 of about 92,718 (279)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Analytical metric tools: A critical reflection on their role, evolution, and future towards a more responsible and fit-for-purpose assessment

Green Analytical Chemistry
The evaluation of analytical methods has expanded from traditional performance criteria toward more holistic approaches that incorporate environmental, practical, and societal dimensions.
Adrián Fuente-Ballesteros, Reem H. Obaydo   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A sustainable RP-HPLC method for simultaneously estimating aceclofenac, paracetamol, and serratiopeptidase with AQbD optimization

Green Analytical Chemistry
This study focused on developing and validating a novel method for the simultaneous estimation of aceclofenac (AFC), paracetamol (PCM), and serratiopeptidase (SPD) using reverse phase high-performance liquid chromatography (RP-HPLC).
Vineetha Rosireddy, Manikandan Krishnan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Greener microvolume UV–Vis and synchrotron radiation circular dichroism workflows for pathlength correction, and pipetting validation and quantified uncertainty for reliable analytical outcomes

Green Analytical Chemistry
Microvolume UV–Vis and synchrotron radiation circular dichroism (SRCD) offer clear sustainability benefits by reducing sample and reagent consumption, yet their adoption is often limited by concerns over optical pathlength variability and low-volume ...
Rohanah Hussain, Tiberiu-Marius Gianga, Jay I Siligardi, Giles S Barrett, Tamás Jávorfi, Giuliano Siligardi   +5 more
doaj   +1 more source

Application of the Semi-Automatic Titration Method Using a Webcam for the Determination of Calcium in Milk and Dairy Products [PDF]

Quantitative determination of calcium content in milk and dairy products is an important analytical task due to the great importance of this element in the human diet.
Alexander Shyichuk, Maria Kowalska, Dorota Ziółkowska, Iryna Shyychuk   +3 more
core   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Systematic review of recent metrics (2020–2025) for greenness, applicability, and analytical performance with guidelines for practical use

Results in Chemistry
In recent years, the demand for eco-friendly analytical methods with practical applicability and high analytical performance has driven the development of numerous evaluation metrics.
Samar H. Elagamy, Adrián Fuente-Ballesteros, Hemanth Kumar Chanduluru, Reem H. Obaydo   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source