Results 91 to 100 of about 92,718 (279)

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington's Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter [PDF]

Huntington's disease (HD), caused by a mutation of the corresponding gene encoding the protein huntingtin (htt), is characterized by progressive deterioration of cognitive and motor functions, paralleled by extensive loss of striatal neurons.
Forro, Laszlo, Bonda, Markus, Jeney, Sylvia, Perrin, Valerie, Miller, Lisa M., Vileno, Bertrand, Runne, Heike, Kretlow, Ariane, Luthi-Carter, Ruth   +8 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A sustainable AQbD-based UHPLC–MS/MS method for the determination of hallucinogenic phenethylamines in urine

Open Chemistry
A systematic Analytical Quality by Design (AQbD) approach was applied to the development and validation of a UHPLC–MS/MS method for the determination of hallucinogenic phenethylamine-derived novel psychoactive substances in urine. Owing to the continuous
Kostić Emilija, Milosavljević Biljana, Simić Jovana, Vujović Maja   +3 more
doaj   +1 more source

Printed platforms for paper-based analytical applications [PDF]

, 2014
Paper-based analytical technologies enable quantitative and rapid analysis of analytes from various application areas including healthcare, environmental monitoring and food safety.
Määttänen, Anni
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Roles of Interfacial Functions in Analytical Chemistry. Construction of a scanning near-field optical microscope using a white-light source.

BUNSEKI KAGAKU, 1998
キセノンランプからの白色光を光源とし,光走査トンネル顕微鏡方式の走査型近接場光学顕微鏡(SNOM)を試作した.微小領域の透過スペクトルを得るための基礎実験として,銅フタロシアニン及び金の2種類の薄膜試料に関して透過スペクトルを得ることを試みた.SNOMで得られた透過スペクトルを市販の分光光度計による測定結果と比較したところ,銅フタロシアニンの薄膜に対しては両者のスペクトルは良く一致したが,金の薄膜の測定結果はSNOMと分光光度計とで反対の傾向を示した.両者の測定結果の違いを金の薄膜に励起される表面プラズモンによって説明した.
TAKAHASHI, Satoshi, FUTAMATA, Masayuki, KOJIMA, Isao   +2 more
openaire   +2 more sources

Differences in Bioaccumulation of Essential and Toxic Elements by White and Red Hawthorn [PDF]

, 2017
Background: Hawthorn species (Crataegus) belonging to the Rosaceae family is one of the most commonly used phytopharmaceuticals against mild cardiovascular diseases. The use of medicinal herbs is regulated by the World Health Organisation regarding their
Stingeder, Gerhard,, Iva Juranovic Cindric, Zeiner, Michaela,, Mihajlov-Konanov, Darija,, Michaela Zeiner, Juranović Cindrić, Iva,, Darija Mihajlov Konanov, Gerhard Stingeder   +7 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A green UFLC approach for vancomycin therapeutic drug monitoring in human plasma: method development, validation, and clinical application in critically ill patients at a tertiary care hospital

Results in Chemistry
Vancomycin remains a cornerstone for treating severe Gram-positive infections, yet its narrow therapeutic index and high inter-individual variability demand precise Therapeutic Drug Monitoring (TDM).
Aparna Inamdar, Nachiket Hanchinal, Narasimha M. Beeraka, Hemanth Vikram Poola Ramachandrappa, Gurupadayya Bannimath, S.R. Sanathan, Umesh Marappa, Akila Prashant, Pramod Kumar Tegginamath, Vladimir N. Nikolenko, Shaheen Taj   +10 more
doaj   +1 more source