Results 91 to 100 of about 92,307 (278)

A green UFLC approach for vancomycin therapeutic drug monitoring in human plasma: method development, validation, and clinical application in critically ill patients at a tertiary care hospital

Results in Chemistry
Vancomycin remains a cornerstone for treating severe Gram-positive infections, yet its narrow therapeutic index and high inter-individual variability demand precise Therapeutic Drug Monitoring (TDM).
Aparna Inamdar, Nachiket Hanchinal, Narasimha M. Beeraka, Hemanth Vikram Poola Ramachandrappa, Gurupadayya Bannimath, S.R. Sanathan, Umesh Marappa, Akila Prashant, Pramod Kumar Tegginamath, Vladimir N. Nikolenko, Shaheen Taj   +10 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride

Talanta Open
Currently, the global push for eco-friendly analytical techniques has altered the priorities of analytical methodologies in accordance with their level of adherence to the principles of green analytical chemistry. Herein, sustainable, sensitive, accurate
Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik   +4 more
doaj   +1 more source

A Review on White Analytical Chemistry

White Analytical Chemistry (WAC) is a sustainable analytical method that combines Green Analytical Chemistry principles with analytical capabilities and practical application. It balances analytical efficiency, environmental safety, and practical application, ensuring accessibility, dependability, and environmental friendliness.
openaire   +2 more sources

A Deep Analytical Investigation of the Aroma Chemistry of Incrocio Bruni 54 and Its Differentiation from Italian White Varieties

Fermentation
Incrocio Bruni 54 is a little-known white grape variety developed in the Marche region (Italy) from a cross between Verdicchio and Sauvignon Blanc to combine aromatic freshness with structure. In light of the growing interest in minor and autochthonous cultivars, this study provides the first comprehensive chemical characterization of the aroma profile
Maurizio Piergiovanni, Martina Moretton, Domenico Masuero, Silvia Carlin   +3 more
openaire   +1 more source

Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach

, 2020
Commensal bacteria must colonize host mucosal surfaces to exert health-promoting properties, and bind to gastrointestinal tract (GIT) mucins via their cell surface adhesins. Considerable effort has been directed towards discovery of pathogen adhesins and
Joshi, Lokesh, Synowsky, Silvia, Cairns, Michael T., Houeix, Benoit, Kane, Marian, Kilcoyne, Michelle   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Use of tri-methylated-β-cyclodextrin and sub-2 μm silica particles for enantiomers separation by nano-liquid chromatography

Journal of Chromatography Open
A short capillary column packed with RP18 sub-2 µm particles was investigated for enantioseparation of selected racemic acidic compounds such as nonsteroidal anti-inflammatory drugs (carprofen, cicloprofen, fenoprofen, flurbiprofen, ibuprofen, indoprofen,
G. D’Orazio, S. Fanali
doaj   +1 more source

Solid-state NMR characterisation of the thermal transformation of a Hungarian white illite [PDF]

, 2005
1H, 27Al, 29Si and 39K solid-state NMR are reported from a Hungarian illite 2:1 clay for samples heated up 1600 °C. This single-phase sample has a small amount of aluminium substitution in the silica layer and very low iron-content (0.4 wt%).
Carroll, Donna L., Kemp, Thomas F., Smith, Mark E., Bastow, T. J.   +3 more
core   +1 more source