Results 101 to 110 of about 495,325 (290)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Development of eco-friendly and sustainable analytical methods for Ritonavir through white analytical chemistry and AQbD approach

Discover Chemistry
The present research study outlines the development and validation of a cost-effective, eco-sustainable, and robust analytical procedure for the quantitative estimation of Ritonavir in bulk and tablet dosage form using UV Spectrophotometry and Reverse ...
Vaibhav Sawale, Prafulla Sabale, Roshni Kunte, Vidya Sabale   +3 more
doaj   +1 more source

Use of tri-methylated-β-cyclodextrin and sub-2 μm silica particles for enantiomers separation by nano-liquid chromatography

Journal of Chromatography Open
A short capillary column packed with RP18 sub-2 µm particles was investigated for enantioseparation of selected racemic acidic compounds such as nonsteroidal anti-inflammatory drugs (carprofen, cicloprofen, fenoprofen, flurbiprofen, ibuprofen, indoprofen,
G. D’Orazio, S. Fanali
doaj   +1 more source

Accurate and precise quantification of Cu,Zn-SOD in human red blood cells using species-specific double and triple IDMS [PDF]

, 2016
Acknowledgements This research was undertaken within the EMRP project HLT05. The EMRP was jointly funded by the EMRP participating countries within EURAMET and the European Union.
Feldmann, Jorg, Gleitzmann, Julia, Raab, Andrea, Schulze, Dirk, Swart, Claudia, Waetzig, Hermann   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Validation of the Medonic CA620/530 Vet 20-ml microcapillary sampler system for hematology testing of feline blood [PDF]

, 2009
The aim of the current study was to compare feline hematologic variables in blood collected in microcapillary tubes (20 ml) and conventional blood tubes with the Medonic CA620/530 Vet in-house hematologic analyzer.
Bourges-Abella, Nathalie, Braun, Jean-Pierre, Geffré, Anne, Reynolds, Brice, Trumel, Catherine   +4 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

White analytical chemistry–aligned eco-friendly, stability-indicating HPLC and HPTLC methods for simultaneous estimation of efonidipine hydrochloride ethanolate and chlorthalidone

Journal of Taibah University for Science
Efonidipine hydrochloride ethanolate and chlorthalidone is used to treat hypertension. However, no stability-indicating HPLC or HPTLC method has been reported for the concurrent analysis of these FDC products.
Ashok H. Akabari, Ketan V. Shah, Jayesh Kushwaha, Jasmina Surati, Ghanshyam G. Tejani, Sarfaraz Ahmed, Seyed Jalaleddin Mousavirad   +6 more
doaj   +1 more source