Results 101 to 110 of about 92,307 (278)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

White analytical chemistry–aligned eco-friendly, stability-indicating HPLC and HPTLC methods for simultaneous estimation of efonidipine hydrochloride ethanolate and chlorthalidone

Journal of Taibah University for Science
Efonidipine hydrochloride ethanolate and chlorthalidone is used to treat hypertension. However, no stability-indicating HPLC or HPTLC method has been reported for the concurrent analysis of these FDC products.
Ashok H. Akabari, Ketan V. Shah, Jayesh Kushwaha, Jasmina Surati, Ghanshyam G. Tejani, Sarfaraz Ahmed, Seyed Jalaleddin Mousavirad   +6 more
doaj   +1 more source

Application of the Semi-Automatic Titration Method Using a Webcam for the Determination of Calcium in Milk and Dairy Products

Quantitative determination of calcium content in milk and dairy products is an important analytical task due to the great importance of this element in the human diet.
Alexander Shyichuk, Maria Kowalska, Dorota Ziółkowska, Iryna Shyychuk   +3 more
core   +1 more source

A study of FT-IR spectroscopy for the identification and classifcation of haematological malignancies [PDF]

, 2009
The aim of the work presented in this thesis was to explore the use of FT-IR spectroscopy, as a complementary clinical tool for haematological laboratory analysis. FT-IR spectra were measured from air-dried and frozen cell lines derived from lymphoma,
Babrah, Jaspreet
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

An Eco‐Friendly and Sensitive Microwave‐Aided Spectrofluorophotometric Characterization of Mirabegron‐Loaded Nanocarriers by Amalgamation of Design of Experiments and White Analytical Chemistry

Luminescence
ABSTRACTMirabegron, a drug for treatment of overactive bladder, has low water solubility and bioavailability. Researchers used quality by design to develop and characterize second‐generation lipid nanocarriers for mirabegron, aiming to provide spatially and temporally sustained drug release. Numerous analytical methodologies for assessing mirabegron in
Pintu Prajapati, Krishna Patel, Pranav Shah, Vilas Surana, Anzarul Haque, Mohd Abul Kalam, Shailesh Shah   +6 more
openaire   +4 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

AI-assisted novel spectral downgrade technique for smart analysis of a quinary pharmaceutical formulation

Green Analytical Chemistry
This study presents sustainable drug analysis solutions for the pharmaceutical industry through intelligent mathematical equations and AI integration, featuring the Downgrading Spectral Resolution Technique (DSRT) monitored and analyzed by AI for the ...
Thirumalai Arunagiri, Alagammai Ganesan, Kanaka Parvathi Kannaiah, Reem Hasan Obaydo, Abdulsalam Ashkar, Hemanth Kumar Chanduluru, Hayam M. Lotfy   +6 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source