Results 81 to 90 of about 197,800 (388)

White-matter hyperintensities in first-episode psychosis [PDF]

British Journal of Psychiatry, 2008
BackgroundWhite-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studiesAimsTo examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorderMethodT2-weighted magnetic ...
Zanetti, Marcus V., Schaufelberger, Maristela S., de Castro, Cláudio C., Menezes, Paulo R., Scazufca, Márcia, McGuire, Philip K., Murray, Robin M., Busatto, Geraldo F.   +7 more
openaire   +2 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

White matter hyperintensity microstructure in amyloid dysmetabolism [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2016
Accumulating evidence suggests associations between cerebrovascular disease (CVD) and Alzheimer’s disease (AD). White matter hyperintensities of presumed vascular origin (WMHs) are increased in subjects with mild cognitive impairment (MCI) and AD, but the exact pathomechanistic link is unknown.
Lisa F, Kalheim, Atle, Bjørnerud, Tormod, Fladby, Kjetil, Vegge, Per, Selnes   +4 more
openaire   +2 more sources

Robust White Matter Hyperintensity Segmentation On Unseen Domain

2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), 2021
Typical machine learning frameworks heavily rely on an underlying assumption that training and test data follow the same distribution. In medical imaging which increasingly begun acquiring datasets from multiple sites or scanners, this identical distribution assumption often fails to hold due to systematic variability induced by site or scanner ...
Zhao, Xingchen, Sicilia, Anthony, Minhas, Davneet, O'Connor, Erin, Aizenstein, Howard, Klunk, William, Tudorascu, Dana, Hwang, Seong Jae   +7 more
openaire   +4 more sources

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

A Novel Frameshift Mutation in Two Siblings with Merosin-deficient Congenital Muscular Dystrophy

Haseki Tıp Bülteni, 2020
We present two siblings with elevated serum creatine kinase concentrations, developmental delay, muscle weakness, and contractures of the lower limbs. Cranial magnetic resonance imaging revealed diffuse white matter hyperintensity in both siblings.
Senem Ayça, Hamide Betül Gerik Çelebi, Sırrı Çam, Muzaffer Polat   +3 more
doaj   +1 more source

Ensemble learning via supervision augmentation for white matter hyperintensity segmentation

Frontiers in Neuroscience, 2022
Since the ambiguous boundary of the lesion and inter-observer variability, white matter hyperintensity segmentation annotations are inherently noisy and uncertain. On the other hand, the high capacity of deep neural networks (DNN) enables them to overfit
Xutao Guo, Xutao Guo, Chenfei Ye, Yanwu Yang, Yanwu Yang, Li Zhang, Li Liang, Shang Lu, Haiyan Lv, Chunjie Guo, Ting Ma, Ting Ma, Ting Ma   +12 more
doaj   +1 more source

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging.

Stroke, 2019
Background and Purpose- White matter hyperintensity (WMH) burden is associated with stroke and cognitive decline. Risk factors associated with the longitudinal progression of WMH in the general population have not been systematically investigated.
E. Scharf, J. Graff‐Radford, S. Przybelski, T. Lesnick, M. Mielke, D. Knopman, G. Preboske, C. Schwarz, M. Senjem, J. Gunter, M. Machulda, K. Kantarci, R. Petersen, C. Jack, P. Vemuri   +14 more
semanticscholar   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Late-life depression, heart failure and frontal white matter hyperintensity: a structural magnetic resonance imaging study

Brazilian Journal of Medical and Biological Research, 2005
The relevance of the relationship between cardiac disease and depressive symptoms is well established. White matter hyperintensity, a bright signal area in the brain on T2-weighted magnetic resonance imaging scans, has been separately associated with ...
J.R.C. Almeida, T.C.T.F. Alves, M. Wajngarten, J. Rays, C.C. Castro, Q. Cordeiro, R.M.S. Telles, R.J. Fraguas, G.F. Busatto   +8 more
doaj   +1 more source