Results 61 to 70 of about 260,120 (295)

Robust automated detection of microstructural white matter degeneration in Alzheimer’s disease using machine learning classification of multicenter DTI data

, 2013
Diffusion tensor imaging (DTI) based assessment of white matter fiber tract integrity can support the diagnosis of Alzheimer’s disease (AD). The use of DTI as a biomarker, however, depends on its applicability in a multicenter setting accounting for ...
Thomas Kirste, Stefan J. Teipel (417223), Stefan J. Teipel, Fellgiebel, Andreas, Karlheinz Hauenstein (417221), Hauenstein, K., Kilimann, I., Harald Hampel, Thomas Kirste (417222), Dyrba, M., Kirste, Thomas, Bokde, A.L.W., Kilimann, Ingo, Annahita Oswald, Pievani, M., Filippi, M., Martin Dyrba (417214), Ewers, Michael, Martin Wegrzyn, Hauenstein, Karlheinz, Ewers, M., Klöppel, Stefan, Arun L. W. Bokde (206207), Pievani, Michela, Oswald, Annahita, Michela Pievani, EDSD, [Study group], Claudia Plant, Klöppel, S., Karlheinz Hauenstein, Andreas Fellgiebel, Michael Ewers (317132), Massimo Filippi, Thomas Meindl, Arun L W Bokde, Martin Dyrba, Plant, C., Wegrzyn, Martin, Teipel, Stefan, Thomas Meindl (417219), Massimo Filippi (110054), Filippi, Massimo, Claudia Plant (417217), Bokde, Arun L. W., Wegrzyn, M., Kirste, T., Hampel, Harald, Andreas Fellgiebel (382233), Stefan Klöppel (261558), Annahita Oswald (417218), Arun L. W. Bokde, EDSD study group, Meindl, Thomas, Michael Ewers, Ingo Kilimann, EDSD Study Group (), Martin Wegrzyn (417215), Stefan Klöppel, Stefan J Teipel, Michela Pievani (417220), Hampel, H., Plant, Claudia, Harald Hampel (183230), Oswald, A., Teipel, Stefan J., Meindl, T., Teipel, S.J., Ingo Kilimann (417216), Fellgiebel, A., Dyrba, Martin   +69 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Morphometric and microstructural characteristics of the brain in patients with temporal lobe epilepsy

Анналы клинической и экспериментальной неврологии
Introduction. The study of morphometric and microstructural characteristics of the brain in patients with temporal lobe epilepsy (TLE) represents one of the most rapidly advancing areas of neuroimaging research.
Marina Yu. Maximova, Anna D. Shitova, Marina V. Krotenkova, Anastasia N. Sergeeva   +3 more
doaj   +1 more source

White matter integrity and gray matter volume.

, 2014
Abbreviations: OFC, orbitofrontal cortex; ACC, anterior cingulate cortex, mOFC, medial orbitofrontal cortex; rACC, rostral part of anterior cingulate cortex.a)Mean fractional anisotropy values for bilateral mOFC-rACC white matter connections.b)Gray ...
Taiga Hosokawa (680857), Toshiyuki Ohtani (680855), Paul G. Nestor (181498), Marek Kubicki (680858), Sylvain Bouix (420340), Yukiko Saito (680856)   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Decrease in the Volume of White Matter Lesions with Improvement of Hepatic Encephalopathy [PDF]

American Journal of Neuroradiology, 2007
MR imaging has found abnormalities compatible with low-grade edema in the brain of patients with cirrhosis that have been related to hepatic encephalopathy. We present 3 patients with hepatic encephalopathy who exhibit supratentorial focal or diffuse white matter lesions compatible with small-vessel brain disease.
B, Mínguez, A, Rovira, J, Alonso, J, Córdoba   +3 more
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Equine Stereotaxtic Population Average Brain Atlas With Neuroanatomic Correlation

Frontiers in Neuroanatomy, 2019
There is growing interest in the horse for behavioral, neuroanatomic and neuroscientific research due to its large and complex brain, cognitive abilities and long lifespan making it neurologically interesting and a potential large animal model for ...
Philippa J. Johnson, Valentin Janvier, Wen-Ming Luh, Marnie FitzMaurice, Teresa Southard, Erica F. Barry   +5 more
doaj   +1 more source

Independent and additive contribution of white matter hyperintensities and Alzheimer’s disease pathology to basal forebrain cholinergic system degeneration

NeuroImage: Clinical, 2023
Objectives: Degeneration of the cholinergic basal forebrain nuclei (CBFN) system has been studied extensively in Alzheimer's disease (AD). White matter hyperintensities are a hallmark of aging as well as a common co-morbidity of AD, but their ...
Christine Kindler, Neeraj Upadhyay, Zeynep Bendella, Franziska Dorn, Vera C. Keil, Gabor C. Petzold   +5 more
doaj   +1 more source

White matter volume in alcohol use disorders: a meta‐analysis [PDF]

Addiction Biology, 2012
ABSTRACTAtrophy of brain white matter (WM) often is considered a signature injury of alcohol use disorders (AUDs). However, investigations into AUD‐related changes in WM volume have yielded complex findings that are difficult to synthesize in a narrative review.
Mollie A, Monnig, J Scott, Tonigan, Ronald A, Yeo, Robert J, Thoma, Barbara S, McCrady   +4 more
openaire   +2 more sources