Results 71 to 80 of about 13,623,762 (302)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Psychological characteristics associated with the brain volume of patients with fibromyalgia

BioPsychoSocial Medicine, 2023
Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing.
Satoshi Izuno, Kazufumi Yoshihara, Masako Hosoi, Sanami Eto, Naoki Hirabayashi, Tae Todani, Motoharu Gondo, Chie Hayaki, Kozo Anno, Akio Hiwatashi, Nobuyuki Sudo   +10 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The relationship between age and average white matter volume.

, 2013
The volume of white matter  = −0.09× age2+9.85× age+41.76× sex+152.56; male  = 1, female  = 0.
Yu-Tzu Wu (277016), Rongjun Yu (277015), Chia-Yuan Chen (277019), Hsiao-Lan Sharon Wang (277014), Wen-Yuan Lee (277017), Ein-Yiao Shen (277020), Ming-Fan Lin (277018)   +6 more
core   +1 more source

Significant clusters for white matter volume loss per timepoint comparison.

, 2023
Overview of the significant clusters for white matter volume loss of time-group comparisons. Different views of the tumor-free hemisphere are displayed.
Roelien H. Enting (15290851), Anouk van der Hoorn (587531), Jesse D. de Groot (15401476), Bart R. J. van Dijken (12152218), Hiska L. van der Weide (15401479)   +4 more
core   +1 more source

Regional White Matter Volumes Correlate with Delay Discounting

PLoS ONE, 2012
A preference for immediate gratification is a central feature in addictive processes. However, the neural structures underlying reward delay tolerance are still unclear. Healthy participants (n = 121) completed a delay discounting questionnaire assessing the extent to which they prefer smaller immediate rewards to larger delayed reward after undergoing
openaire   +5 more sources

Genetic Variation in White Matter Hyperintensity Volume in the Framingham Study [PDF]

Stroke, 2004
Background and Purpose— In a previous study of normal elderly male twins, the heritability of quantitative white matter hyperintensity (WMH) volume has been estimated to be high (0.73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and ...
Larry D, Atwood, Philip A, Wolf, Nancy L, Heard-Costa, Joseph M, Massaro, Alexa, Beiser, Ralph B, D'Agostino, Charles, DeCarli   +6 more
openaire   +2 more sources

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Gray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.

PLoS ONE, 2018
BackgroundBrain volume loss is an important surrogate marker for assessing disability in MS; however, contribution of gray and white matter to the whole brain volume loss needs further examination in the context of specific MS treatment.ObjectivesTo ...
Fredrika Koskimäki, Jacqueline Bernard, Jeong Yong, Nancy Arndt, Timothy Carroll, Seon-Kyu Lee, Anthony T Reder, Adil Javed   +7 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source