Results 71 to 80 of about 260,120 (295)

Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation.

, 2015
In neuroimaging studies, pathologies can present themselves as abnormal intensity patterns. Thus, solutions for detecting abnormal intensities are currently under investigation.
Willem H. Bouvy, Sudre, Carole H., Bouvy, W, Josephine Barnes, Biessels, G, Biessels, Geert Jan, Barnes, Josephine, Sudre, C, Ourselin, Sebastien, Bouvy, Willem H., Sebastien Ourselin, Cardoso, MJ, Ourselin, S, M. Jorge Cardoso, Geert Jan Biessels, Cardoso, M. Jorge, Barnes, J, Sudre, Carole H.; id_orcid, Cardoso, M. Jorge; id_orcid, Carole H. Sudre   +19 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Associations between white matter lesion volume and white matter tissue integrity parameters.

, 2014
Associations between white matter lesion volume and white matter tissue integrity parameters.
Efrat Kliper (621175), Einor Ben Assayag (621176), Moran Artzi (297217), Shani Shenhar-Tsarfaty (621179), Orna Aizenstein (297223), Anat Mike (621181), Dafna Ben Bashat (297216), Amos D. Korczyn (621178), Natan M. Bornstein (621183), Ludmila Shopin (621182), Ricardo Tarrasch (621177), Hen Hallevi (621180)   +11 more
core   +1 more source

Color fusion of magnetic resonance images improves intracranial volume measurement in studies of aging [PDF]

, 2012
Background: Comparison of intracranial volume (ICV) measurements in different subpopulations offers insightinto age-related atrophic change and pathological loss of neuronal tissue.
Deary, Ian J., Deary, Ian, Maniega, Susana Muñoz, Valdés Hernández, Maria del C., Royle, Natalie, Jackson, Michael, Bastin, Mark E., Penke, Lars, Munoz-Maniega, Susana; id_orcid, Valdes Hernandez, Maria, Wardlaw, Joanna, Jackson, Michael R., Bastin, Mark   +12 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Psychological characteristics associated with the brain volume of patients with fibromyalgia

BioPsychoSocial Medicine, 2023
Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing.
Satoshi Izuno, Kazufumi Yoshihara, Masako Hosoi, Sanami Eto, Naoki Hirabayashi, Tae Todani, Motoharu Gondo, Chie Hayaki, Kozo Anno, Akio Hiwatashi, Nobuyuki Sudo   +10 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Regional White Matter Volumes Correlate with Delay Discounting

PLoS ONE, 2012
A preference for immediate gratification is a central feature in addictive processes. However, the neural structures underlying reward delay tolerance are still unclear. Healthy participants (n = 121) completed a delay discounting questionnaire assessing the extent to which they prefer smaller immediate rewards to larger delayed reward after undergoing
openaire   +5 more sources

Decline in intelligence is associated with progression in white matter hyperintensity volume [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2005
To quantify the time course of white matter hyperintensities (WMH) and assess the association between progression and cognitive decline in non-demented octogenarians.From a Danish cohort of 698 people born in 1914, 26 participated in neuropsychological assessment (Wechsler adult intelligence scale) initiated at age 50, including cognitive testing and ...
Garde, E, Mortensen, Erik Lykke, Rostrup, E, Paulson, O B   +3 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source