Results 51 to 60 of about 142,550 (285)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Study on the degree of enamel damage according to different etching protocols used for fixed orthodontic appliances [PDF]

Romanian Journal of Stomatology, 2019
Along with whitening techniques, fixed orthodontic appliances (FOA) is currently one of the patients' favourite manoeuvres looking for aesthetic appearance.
Anamaria Florescu, Cornelia Bîcleşanu, Alexandru Burcea, Ştefan Manea, Andrei Angheluţă   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Understanding the spatial and topographic characteristics of enamel white spot lesions for targeted remineralization

Journal of Oral Biology and Craniofacial Research
Introduction: White spot lesions are opaque, chalky white or yellowish discolorations on the surface of teeth that result from the demineralization of the tooth structure.
Devanshi Rajesh Chhabria, Ramya Ramadoss, MDS.,PhD, Hema Shree K, MDS, Sandhya Sundar, MDS, Suganya Panneer Selvam, MDS, Pratibha Ramani, MDS.,PhD   +5 more
doaj   +1 more source

White Spot Lesions: A Serious but Often Ignored Complication of Orthodontic Treatment

Open Dentistry Journal, 2022
The objective of this narrative review is to present an overview of the prevalence, clinical manifestation, diagnosis, and latest advances on white spot lesions. White spot lesions have been defined as the earliest stage of demineralization on
A. Marya, A. Venugopal, M. Karobari, Dinesh Rokaya   +3 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of Resin Infiltration and Microabrasion on the Microhardness of the Artificial White Spot Lesions (An in Vitro Study)

Journal of Baghdad College of Dentistry, 2022
: Background: White spot lesion is the first visible sign of dental caries that is characterized by demineralized lesion underneath an intact surface. Several studies demonstrated that they could be treated using noninvasive techniques like the use of ...
Reem Majeed, H. J. Al-Mamoori, Aseel Haidar, M. J. A. Haidar   +3 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparison of remineralizing efficacy of two novel preparation of arginine and theobromine on white spot lesion - an in vitro SEM analysis

Clinical and Investigative Orthodontics
Purpose Evaluation of the efficacy of two novel formulations of arginine and theobromine in remineralizing artificial enamel defects using in vitro testing techniques- Microhardness and SEMMaterials and methods Enamel slabs measuring 3 mm by 3 mm by 1.5 ...
Shifo Savio F, Nivethigaa Balakrishnan, Aravind Kumar Subramanian   +2 more
doaj   +1 more source

Effect of Xylitol Lozenge on Remineralization of Artificial Carious Lesions - In Situ

Turkish Journal of Orthodontics, 2009
The purpose of this study was to evaluate the effect of lozenges containing xylitol on in situ remineralization of artificial carious lesions. Eleven patients (aged between 12 and 15 years old) treated by fixed orthodontic therapy with bilateral ...
Sabri İlhan Ramoğlu, Sıddık Malkoç, Zafer Sarı, Abdulkadir Şengün   +3 more
doaj   +1 more source