Results 61 to 70 of about 60,772 (341)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Study on the degree of enamel damage according to different etching protocols used for fixed orthodontic appliances [PDF]

Romanian Journal of Stomatology, 2019
Along with whitening techniques, fixed orthodontic appliances (FOA) is currently one of the patients' favourite manoeuvres looking for aesthetic appearance.
Anamaria Florescu, Cornelia Bîcleşanu, Alexandru Burcea, Ştefan Manea, Andrei Angheluţă   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Infrared imaging spectroscopy of skin cancer lesions [PDF]

, 2016
Skin cancer is a disease of the twenty-first century since, unfortunately, being tan is associated to be healthy and good looking. UV radiation produces one of the most aggressive kinds of skin cancer: melanoma; once the damage is done there is no other ...
Rey Barroso, Laura
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Comparison of remineralizing efficacy of two novel preparation of arginine and theobromine on white spot lesion - an in vitro SEM analysis

Clinical and Investigative Orthodontics
Purpose Evaluation of the efficacy of two novel formulations of arginine and theobromine in remineralizing artificial enamel defects using in vitro testing techniques- Microhardness and SEMMaterials and methods Enamel slabs measuring 3 mm by 3 mm by 1.5 ...
Shifo Savio F, Nivethigaa Balakrishnan, Aravind Kumar Subramanian   +2 more
doaj   +1 more source

Effect of topical fluoride application and diode laser-irradiation on white spot lesions of human enamel

Saudi Dental Journal, 2021
Objectives: This study aims to evaluate the effectiveness of topical fluoride application and diode laser-irradiation on the hardness of demineralized enamel and to evaluate the esthetic improvement of the white spot lesions (WSLs) using a visual analog ...
Mohammad A. Alqahtani, Naif A. Almosa, Khalid A. Alsaif, Naif M. Alsaif, Yazeed J. Aljaser   +4 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Effect of Xylitol Lozenge on Remineralization of Artificial Carious Lesions - In Situ

Turkish Journal of Orthodontics, 2009
The purpose of this study was to evaluate the effect of lozenges containing xylitol on in situ remineralization of artificial carious lesions. Eleven patients (aged between 12 and 15 years old) treated by fixed orthodontic therapy with bilateral ...
Sabri İlhan Ramoğlu, Sıddık Malkoç, Zafer Sarı, Abdulkadir Şengün   +3 more
doaj   +1 more source

Effectiveness of laser fluorescence–based device in detecting the extent of re-mineralisation in primary teeth compared to the conventional method: An In vitro study

Indian Journal of Dental Research, 2022
Background: Laser fluorescence (LF)–based clinical device DIAGNOdent™ is at present being used to detect caries. Can the same be used to detect therapeutic remineralisation of early white spot lesions?
Megha J Nair, Arathi Rao, K Jayaprakash, Srikant Natarajan, Vasavi Kumblekar, B S Suprabha   +5 more
doaj   +1 more source