Results 51 to 60 of about 60,772 (341)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Fluoride Varnish May Improve White Spot Lesions [PDF]

open access: yes, 2011
Design A randomised, parallel-group, controlled clinical trial. Intervention The test group had fluoride varnish applied onto the tooth surfaces with WSLs using a miniature cotton swab or brush and advised not to brush for four hours.
Stafford, Gary L
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Comparison of the effects of toothpastes containing nanohydroxyapatite and fluoride on white spot lesions in orthodontic patients: A randomized clinical trial

open access: yesDental Research Journal, 2020
Background: Studies show that fluoride (F) and nano-hydroxyapatite (nano-HA) would result in remineralization of white spot lesions (WSLs), which are among the most prevalent consequences of fixed orthodontic treatment.
Mohammadreza Badiee   +5 more
doaj   +1 more source

Saprolegnia on roach (Leuciscus rutilus) and carp (Cyprinus carpio) [Translation from: Acta zool.pathol.Antverpiensia 43 107-123, 1976] [PDF]

open access: yes, 1979
There is, in nature, as well as in the aquarium, a parasitic disease known as 'mousse' and which attacks predominantly fish. It is caused by Phycomycete fungi, genus Saprolegnia.
Nolard-Tintigner, N.
core  

Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]

open access: yes, 2019
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi   +5 more
core   +1 more source

White Spot Lesions

open access: yesInternational Journal of Clinical Case Reports, 2015
White spot lesions are an early stage of tooth decay formation. White spot lesions are commonly associated with the fixed orthodontic treatment and it poses a significant problem in the clinical setup. These lesions are caused by tooth demineralization which results in visible enamel changes.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Understanding the spatial and topographic characteristics of enamel white spot lesions for targeted remineralization

open access: yesJournal of Oral Biology and Craniofacial Research
Introduction: White spot lesions are opaque, chalky white or yellowish discolorations on the surface of teeth that result from the demineralization of the tooth structure.
Devanshi Rajesh Chhabria   +5 more
doaj   +1 more source

Incidence of White Spot Lesion During Fixed Orthodontic Treatment

open access: yesTurkish Journal of Orthodontics, 2013
Objective:Development of white spot lesion (WSL) is one of the main side effects of fixed orthodontic treatment (FOT). The aim of this study was to investigate the incidence of WSL during FOT and to determine the significant factors.Materials and Methods:
Mehmet Akin   +3 more
doaj   +1 more source

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