Results 61 to 70 of about 13,879 (238)

White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp.

PLoS Pathogens, 2022
Previous studies have shown that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has antiviral functions or is beneficial for viral replication, however, the detail mechanisms by which mTORC1 enhances viral infection remain ...
Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang   +4 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Frontiers in Immunology, 2022
The TRIpartite Motif (TRIM) proteins play key roles in cell differentiation, apoptosis, development, autophagy, and innate immunity in vertebrates.
Mingzhe Sun, Shihao Li, Shihao Li, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Jianhai Xiang, Fuhua Li, Fuhua Li, Fuhua Li, Fuhua Li   +11 more
doaj   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.

PLoS Pathogens, 2014
In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the late ...
Mei-An Su, Yun-Tzu Huang, I-Tung Chen, Der-Yen Lee, Yun-Chieh Hsieh, Chun-Yuan Li, Tze Hann Ng, Suh-Yuen Liang, Shu-Yu Lin, Shiao-Wei Huang, Yi-An Chiang, Hon-Tsen Yu, Kay-Hooi Khoo, Geen-Dong Chang, Chu-Fang Lo, Han-Ching Wang   +15 more
doaj   +1 more source

Cloning and Analysis of Gene Expression of Two Toll Receptors in Freshwater Pearl Mussel Hyriopsis cumingii

Frontiers in Physiology, 2018
Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5) from triangle sail mussel Hyriopsis cumingii.
Ying Huang, Ying Huang, Keke Han, Qian Ren, Qian Ren   +4 more
doaj   +1 more source

Characterization of a novel binding protein for Fortilin/TCTP--component of a defense mechanism against viral infection in Penaeus monodon. [PDF]

PLoS ONE, 2012
The Fortilin (also known as TCTP) in Penaeus monodon (PmFortilin) and Fortilin Binding Protein 1 (FBP1) have recently been shown to interact and to offer protection against the widespread White Spot Syndrome Virus infection. However, the mechanism is yet
Tanate Panrat, Patuma Sinthujaroen, Benjamas Nupan, Warapond Wanna, Martti Tapani Tammi, Amornrat Phongdara   +5 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Delayed mortality of juvenile shrimp Penaeus vannamei challenged to White spot syndrome virus (WSSV) previously exposed to Infectious hypodermal and haematopoietic necrosis virus (IHHNV) or inactivated WSSV

Brazilian Journal of Veterinary Pathology, 2015
In Ecuador, the development and sustainability of the cultured white shrimp, Penaeus vannamei, has been threatened by the occurrence of several viral pathogens, Infectious hypodermal and haematopoietic necrosis virus (IHHNV) and White spot syndrome virus
José Melena, Fabricio Echeverría, Fanny Panchana, Irma Betancourt, Rosa Santander, Jimmy Candell, Jean-Robert Bonami   +6 more
doaj   +1 more source

Contribution of the argonaute-1 isoforms to invertebrate antiviral defense. [PDF]

PLoS ONE, 2012
Argonaute (Ago) protein, the central component of the RNA interference (RNAi) pathway, plays important roles in host innate antiviral immunity. Most organisms harbor a large number of different Ago proteins and isoforms; however, the roles of Ago ...
Tianzhi Huang, Xiaobo Zhang
doaj   +1 more source