Results 61 to 70 of about 101,065 (262)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

On non-metric continua that support Whitney maps

Topology and its Applications, 2014
In the present discussion, a \textit{continuum} is a connected compact Hausdorff space. For any compact Hausdorff \(X\), \(2^X\) is the hyperspace of closed nonempty subsets of \(X\), endowed with the Vietoris topology. \(2^X\) is also well known to be compact Hausdorff in this topology; important closed subspaces include \(F_n(X)\) (the subsets with ...
Smith, Michel, Stone, Jennifer
openaire   +2 more sources

Effects of training nursing process using the concept map on caring self-efficacy of nursing students in pediatric departments

Journal of Education and Health Promotion
BACKGROUND: Self-efficacy is task-specific, and Professional self-efficacy has been introduced as a factor affecting providing quality nursing care. This study aimed to determine the effects of training the nursing process using the concept map on the ...
Azam Alavi, Forogh Okhovat
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spaces of maps into topological group with the Whitney topology

Topology and its Applications, 2010
11 ...
Banakh, Taras, Mine, Kotaro, Sakai, Katsuro, Yagasaki, Tatsuhiko   +3 more
openaire   +3 more sources

More hemodynamic changes in hypertensive versus non-hypertensive patients undergoing breast cancer surgery in general anesthesia - a prospective clinical study [PDF]

Medicinski Glasnik, 2009
Aim Preoperative comorbidity may significantly influence theconduction of anesthesia and patients’ outcome. The aim of thisstudy was to compare a number of anesthetic interventions and theuse of non-anesthetic drugs in hypertensive and non ...
Darija Azenić-Venžera, Kata Šakić, Jozo Kristek, Ivana Drenjančević-Haršanji, Andreja Rakipović-Stojanović, Gordana Brozovic, Slavica Kvolik, Dražen Vidović, Borna Kovačić, Gordana Kristek   +9 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chaotic Status-Based Optimization: Deterministic Chaos Integration for Congress on Evolutionary Computation-2022 Benchmarks and Engineering Design Problems [PDF]

Advances in Engineering and Intelligence Systems
Metaheuristic optimizers often suffer from premature convergence and instability in multimodal and constrained search landscapes. Although the recently proposed Status-Based Optimization demonstrates competitive performance, its reliance on stochastic ...
Dhara Buch, Hitarth Buch
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source