Results 61 to 70 of about 309 (92)

Spectrum and signals of medication-associated cognitive disorder: a comprehensive disproportionality analysis with cross-database validation

Frontiers in Pharmacology
ObjectiveThe clinical risk of cognitive disorders linked to various drugs is not well-defined. This study aimed to identify medications with notable signals for drug-related cognitive disorders and evaluate whether their US Food and Drug Administration ...
Hao Wen, Yajie Dong, Ruiting Wang
doaj   +1 more source

A Real-World Data Analysis of Adverse Drug Reactions Associated with Neuroprotective Agents: Insights from WHO-VigiAccess

Abstract Introduction: Sensorineural hearing loss (SNHL) is a common sensory disorder characterized by auditory nerve damage and cochlear dysfunction, often driven by oxidative stress, excitotoxicity, and neuroinflammation. Neuroprotective agents such as Cerebrolysin, Citicoline, Flunarizine, and Mecobalamin have demonstrated efficacy in ...
Shuainan Chen, Yurui Zhuang, Rujie Li, Chuan Chang, Guojun Zheng   +4 more
openaire   +1 more source

Post-marketing safety signals and report-level ARIA-E stratification for lecanemab and donanemab: an integrated FAERS and WHO-VigiAccess pharmacovigilance study

Therapeutic Advances in Drug Safety
Background: Anti-β-amyloid monoclonal antibodies provide a disease-modifying treatment approach for Alzheimer’s disease, but post-marketing safety concerns remain, particularly amyloid-related imaging abnormalities (ARIA).
Wei-Yang Xue, Xi Li, Wen-Ting Li, Bao-Zhi Qin, Cong-Zhi Wang, Tao Liu, Min Wang   +6 more
doaj   +1 more source

Muscle toxicity reports in FAERS: a disproportionality analysis with focus on rhabdomyolysis and cross-database assessment

Frontiers in Pharmacology
ObjectiveMuscle toxicity can significantly impair quality of life and may be life-threatening in severe cases. Although statins are well known for their risk of muscle toxicity, a comprehensive evaluation of other implicated drugs remains limited.
Lei Zhang, Lei Zhang, Yuqi Wang, Fang Wang, Fang Wang, Kaiyun Ji, Kaiyun Ji, Lili Yang, Jia Li, Jia Li   +9 more
doaj   +1 more source

Global pharmacovigilance analysis of antimicrobials used in periodontal therapy: safety profiles of minocycline, doxycycline, and chlorhexidine

Head & Face Medicine
Background Minocycline, doxycycline, and chlorhexidine are widely used as adjuncts to non-surgical periodontal therapy. Although their efficacy has been demonstrated in clinical trials, comparative real-world safety data across diverse populations remain
Wanchen Ning, Xiangyu Huang, Simin Li, Linxin Jiang, Daniel R. Reissmann, Deborah Kreher, Gerhard Schmalz, Hongxing Chu, Shaohong Huang   +8 more
doaj   +1 more source

Immune-related adverse-event signals of durvalumab: cross-database pharmacovigilance analysis of WHO-VigiAccess and FAERS with comparative assessment versus atezolizumab

Abstract Background: Durvalumab has become a key programmed death-ligand 1 (PDL1) inhibitor in modern oncology, particularly in thoracic malignancies. As its clinical use expands, immune-related adverse events (irAEs) have emerged as a major safety concern.
Furong Sun, Qinwei Wu, Jing Li, Shouzhen Liu, Jie Hua, Yuzhu Gao   +5 more
openaire   +1 more source

Investigating the Status of WHO VigiAccess Adverse Drug Event Reporting and Exploring its Potential for Application Using Anti-Obesity Agents as Examples

The Journal of Internal Korean Medicine
Objectives: This study reviewed the status of adverse event (AE) reporting in VigiAccess using anti-obesity agents as examples and explored the possibility of its use and future challenges.Methods: AE reports related to some representative drugs among herbal medicines (HMs), complex HM prescriptions, ingredients of supplements, and over-the-counter and
openaire   +1 more source

Status of reports of adverse events related to botanical herbal medicines with toxic precautions officially managed by Korean government: A descriptive analysis from WHO VigiAccess

Journal of Korean Medicine
Objectives: This study was aimed to review the global status of adverse event (AE) reports and the characteristics of the reported AEs of plants managed as herbal medicines (HMs) with toxic precautions in Korea.Methods: This is a cross-sectional quantitative study that analyzed information available through VigiAccess, a website that provides ...
openaire   +1 more source

Comparative real-world safety profiles of caspofungin, micafungin, and anidulafungin: a disproportionality analysis based on FAERS and VigiAccess databases. [PDF]

Front Pharmacol
Chen J, Chen C, Lin X, Yan J, Zheng Y, Chen P, Li J.   +6 more
europepmc   +1 more source

Post-marketing safety signals of Wilson's disease therapies: evidence from FAERS and VigiBase. [PDF]

Orphanet J Rare Dis
Tezel-Yalçın H, Yalçın N, Allegaert K, Erkekoğlu P.   +3 more
europepmc   +1 more source