Results 191 to 200 of about 155,426 (291)

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells. [PDF]

Nat Commun
Kim K, Armand J, Kim S, Yang HW.
europepmc   +1 more source

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease. [PDF]

J Dev Biol, 2023
Schvarzstein M, Alam F, Toure M, Yanowitz JL.   +3 more
europepmc   +1 more source

Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep

Animal Research and One Health, EarlyView.
Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang, Wei Dai, Jiqiang Liu, Zhengguang Wang   +3 more
wiley   +1 more source

Distinct patterns of genome size evolution in each bryophyte lineage are not correlated with whole genome duplication. [PDF]

Ann Bot
Patel N, Budke JM, Bainard JD.
europepmc   +1 more source

Dynamics of Gene Loss following Ancient Whole-Genome Duplication in the Cryptic Paramecium Complex. [PDF]

Mol Biol Evol, 2023
Gout JF, Hao Y, Johri P, Arnaiz O, Doak TG, Bhullar S, Couloux A, Guérin F, Malinsky S, Potekhin A, Sawka N, Sperling L, Labadie K, Meyer E, Duharcourt S, Lynch M.   +15 more
europepmc   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Expression pattern of resynthesized allotetraploid Capsella is determined by hybridization, not whole-genome duplication. [PDF]

New Phytol, 2023
Duan T, Sicard A, Glémin S, Lascoux M.
europepmc   +1 more source

Early evolutionary history of the seed

Biological Reviews, EarlyView.
ABSTRACT The seed is an essential stage in the life history of gymnospermous and angiospermous plants, facilitating both their survival and dispersal. We reappraise knowledge of the evolutionary history of the gymnospermous seed, from its origin in the late Devonian through to the well‐known end‐Permian extinctions – an interval encompassing the ...
Richard M. Bateman, Alan R. T. Spencer, Jason Hilton   +2 more
wiley   +1 more source

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers. [PDF]

Cancer Res, 2022
Prasad K, Bloomfield M, Levi H, Keuper K, Bernhard SV, Baudoin NC, Leor G, Eliezer Y, Giam M, Wong CK, Rancati G, Storchová Z, Cimini D, Ben-David U.   +13 more
europepmc   +1 more source