Results 231 to 240 of about 97,540 (294)

The immediate metabolomic effects of whole-genome duplication in the greater duckweed, Spirodela polyrhiza. [PDF]

Am J Bot
Wu T, Bafort Q, Mortier F, Almeida-Silva F, Natran A, Van de Peer Y.   +5 more
europepmc   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, EarlyView.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

The role of transposon activity in shaping <i>cis</i>-regulatory element evolution after whole-genome duplication. [PDF]

Genome Res
Monsen Ø, Grønvold L, Datsomor A, Harvey T, Kijas J, Suh A, Hvidsten TR, Sandve SR.   +7 more
europepmc   +1 more source

Impact of ovarian preservation on survival for premenopausal women with early‐stage endometrial carcinoma: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Up to 14% of women with early‐stage endometrial carcinoma (EEC) are diagnosed before menopause. Although ovarian preservation (OP) within surgical staging might avoid surgical menopause, its rate remains low in clinical practice, probably because the impact of OP on survival outcomes is unclear.
Antonio Raffone, Diego Raimondo, Daniele Neola, Manuela Maletta, Marisol Doglioli, Antonio Travaglino, Carlo Ronsini, Maria Giovanna Vastarella, Stefano Ferla, Francesco Cosentino, Pasquale De Franciscis, Renato Seracchioli, Luigi Cobellis   +12 more
wiley   +1 more source

Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication. [PDF]

Life Sci Alliance
Lau TT, Ma HT, Poon RY.
europepmc   +1 more source

Artificial intelligence–driven decoupling structure–activity relationship for lithium‐ion batteries

InfoScience, EarlyView.
Artificial intelligence can efferently accelerate the high‐throughput screening of battery materials, the analysis of multiphase mechanisms, and the precise prediction of capacity and cycle life. This review systematically summarizes the applications of machine learning (ML) in decoupling the complex structure‐activity relationships of lithium‐ion ...
Tao Wang, Yuhang Meng, Tianhao Chen, Xiangfen Jiang, Yoshio Bando, Jinjue Zeng, Xuebin Wang   +6 more
wiley   +1 more source

Whole-genome duplication in an algal symbiont bolsters coral heat tolerance. [PDF]

Sci Adv
Dougan KE, Bellantuono AJ, Kahlke T, Abbriano RM, Chen Y, Shah S, Granados-Cifuentes C, van Oppen MJH, Bhattacharya D, Suggett DJ, Rodriguez-Lanetty M, Chan CX.   +11 more
europepmc   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Parallel Selection in Domesticated Atlantic Salmon from Divergent Founders Including on Whole-Genome Duplication-derived Homeologous Regions. [PDF]

Genome Biol Evol
Buso P, Diblasi C, Manousi D, Kwak JS, Vera-Ponce de Leon A, Stenløkk K, Barson N, Saitou M.   +7 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source