Results 171 to 180 of about 3,960,512 (303)

Whole Genome Sequencing Infographic

This infographic describes Whole Genome Sequencing for M ...

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Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Zymomonas mobilis mobilis NRRL B-4492 genome sequencing

, 2019
Whole genome sequencing of Zymomonas mobilis strain for genetic engineering and biofuel ...
DOE Joint Genome Institute (17854997)
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Accurate detection of sub-1% frequency somatic mutations by whole-genome sequencing. [PDF]

Am J Hum Genet
Jang Y, Gardiner S, Wang Y, Natu A, Dehankar MK, Tomasini L, Panda A, Cibulskis C, Anderson L, Coorens THH, Oh JW, Urban AE, Ardlie K, Marth G, Vaccarino FM, Abyzov A.   +15 more
europepmc   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Zymomonas mobilis mobilis NRRL B-4286 genome sequencing

, 2019
Whole genome sequencing of Zymomonas mobilis strain for genetic engineering and biofuel ...
DOE Joint Genome Institute (17854997)
core  

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Zymomonas mobilis mobilis NRRL B-14022 genome sequencing

, 2019
Whole genome sequencing of Zymomonas mobilis strain for genetic engineering and biofuel ...
DOE Joint Genome Institute (17854997)
core  

Whole-Genome Sequencing in Diagnostics of Unsolved Cases of Inherited Retinal Diseases. [PDF]

Int J Mol Sci
Ogorodova N, Stepanova A, Geletskaia P, Kadyshev V, Zinchenko R, Kuznetsova S, Khalanskaya O, Monakhova A, Beskorovainy N, Zabnenkova V, Ryzhkova O, Severinov K, Bychkov I, Polyakov A, Kutsev S, Shchagina O.   +15 more
europepmc   +1 more source