Results 191 to 200 of about 3,779,882 (303)

«Whole genome sequencing»

Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2017
Meinel, Dominik M, Seth-Smith, Helena M.B., Egli, Adrian   +2 more
openaire   +3 more sources

Strategies for integrating whole-genome sequencing into antimicrobial resistance surveillance. [PDF]

BMC Genomics
On Y, Yoon EJ.
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Citywide implementation of a rapid whole-genome sequencing program for critically ill pediatric patients. [PDF]

Nat Med
Rabea F, Aljasmi I, Jain R, Ramaswamy S, Taylor A, Shenbagam S, Chekroun I, Sinha S, El Naofal M, Yaslam S, Alfalasi R, Khadija S, Farag M, AlHajjaj S, Almadhoun F, Sharaf R, Khyriem C, Abulhoul H, Elabd H, Mustafa M, Almarri M, Du Plessis S, AlKhnbashi OS, Majid I, Buhumaid R, Al Suwaidi H, AlAwadhi M, AlKhayat A, Alsheikh-Ali A, Zahraa J, Shankar S, Abou Tayoun A.   +31 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting. [PDF]

PLoS One
Waggle KD, Griffith MP, Rokes AB, Rangachar Srinivasa V, Nawrocki EM, Ereifej D, Patrick R, Coyle H, Chaudhary S, Raabe NJ, Shutt K, Sundermann AJ, Cooper VS, Harrison LH, Pless LL.   +14 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Whole genome sequencing of measles viruses: the benefit for outbreak investigation, The Netherlands, 2013-2014. [PDF]

Virus Genes
Bodewes R, Maissan C, van de Nes-Reijnen L, Boter M, van den Boom SC, Zwagemaker F, Hahné S, Woudenberg T, Ruijs WLM, Koopmans MPG, Reusken CBEM, de Vries RD, Molenkamp R, de Swart RL, Munnink BO.   +14 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source