Results 211 to 220 of about 912,763 (246)

Whole-Genome Sequencing in Personalized Therapeutics

Clinical Pharmacology & Therapeutics, 2012
Eleven years since the initial drafts of the human genome were published, we have begun to see the first examples of the application of whole-genome sequencing to personalized diagnosis and therapeutics. The exponential decline in sequencing costs and the constant improvement in these technologies promise to further advance the use of a patient's full ...
P, Cordero, E A, Ashley
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Tagmentation-based whole-genome bisulfite sequencing

Nature Protocols, 2013
Epigenetic modifications such as carbon 5 methylation of the cytosine base in a CpG dinucleotide context are involved in the onset and progression of human diseases. A comprehensive understanding of the role of genome-wide DNA methylation patterns, the methylome, requires quantitative determination of the methylation states of all CpG sites in a genome.
Qi, Wang, Lei, Gu, Andrew, Adey, Bernhard, Radlwimmer, Wei, Wang, Volker, Hovestadt, Marion, Bähr, Stephan, Wolf, Jay, Shendure, Roland, Eils, Christoph, Plass, Dieter, Weichenhan   +11 more
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Whole exome and whole genome sequencing

Current Opinion in Pediatrics, 2011
The purpose of this review is to describe the new DNA sequencing technologies referred to as next-generation sequencing (NGS). These new methods are becoming central to research in human disease and are starting to be used in routine clinical care.Advances in instrumentation have dramatically reduced the cost of DNA sequencing.
David, Bick, David, Dimmock
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WHOLE GENOME SEQUENCING

European Neuropsychopharmacology, 2022
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Whole-Genome Sequencing Recommendations

2016
Recent technological developments have revolutionized the way we perform genetic analyses. In particular whole-genome sequencing provides access to the entire genetic makeup of an individual, and it is now an affordable approach for many research groups. As a consequence genome sequencing is pervading many fields of biological research.
Toni Gabaldón, Tyler S. Alioto
openaire   +1 more source

Cancer Whole-Genome Sequencing

The Journal of Molecular Diagnostics, 2021
Andrew C. Nelson, Sophia L. Yohe
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30X whole genomic sequencing

The patient had severe early-onset refractory seizures who had a compound heterozygous deletion involving an exon 6 to 8 deletion and a discontinuous deletion of intron 5 and exon 6 in the WWOX ...
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Whole-Genome Sequencing

2013
James Luiselli, Francesca Happé, Hillary Hurst, Stephanny Freeman, Gerald Goldstein, Carla Mazefsky, Alice S. Carter, Alan S. Kaufman, Elizabeth Schoen Simmons, Elizabeth R. Eernisse, Katherine Tsatsanis, Faye Fluit, Bonnie Klein-Tasman, Adam Feinstein, Allison Kahl, Shirley Poyau, Catherine R. G. Jones, Fred R. Volkmar, Julie M. Wolf, Aparna Nadig, Paul Cavanagh, Rhea Paul, Diana B. Newman   +22 more
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Treatment of muscle‐invasive and advanced bladder cancer in 2020

Ca-A Cancer Journal for Clinicians, 2020
Vaibhav G Patel, William K Oh, Matthew D Galsky   +2 more
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Interpreting Whole-Genome Sequencing—Reply

JAMA, 2014
Frederick, Dewey, Euan, Ashley, Thomas, Quertermous   +2 more
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