Results 241 to 250 of about 3,779,882 (303)

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Whole genome sequencing of three cloacal bacterial isolates from migratory birds. [PDF]

Microbiol Resour Announc
Kumar G, Pagano SS, Cavanaugh N, Hudson AO, Savka MA.   +4 more
europepmc   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Genetic Heterogeneity of Inborn Errors of Immunity Revealed by Whole-Genome Sequencing: Insights from a Russian Patient Cohort. [PDF]

Int J Mol Sci
Petrusenko Y, Savin T, Sedykh A, Chekanov N, Klimuk E, Ostankova Y, Kuznetsova R, Chernyshova A, Milichkina A, Totolian A, Severinov K.   +10 more
europepmc   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Clinical utility of 'Shaken' biopsies for whole-genome sequencing. [PDF]

J Clin Pathol
Nelan R, Mijuskovic M, Hughes M, Becq J, Kingsbury Z, Tsogka E, He M, Vucenovic D, Craig C, Elgar G, Levey P, Suaris T, Walsh E, Ross M, Jones JL.   +14 more
europepmc   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Application of metagenomics for the detection of foodborne pathogens

, 2019
Grützke, Josephine
core  

Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma. [PDF]

Nat Commun
Steemers AS, van Roosmalen MJ, Hagelaar R, Trabut L, Verheul M, de Kanter JK, Jongsma S, Derks LLM, Blackwell AR, Meyer-Wentrup F, van Boxtel R.   +10 more
europepmc   +1 more source