Results 241 to 250 of about 3,960,512 (303)

Citywide implementation of a rapid whole-genome sequencing program for critically ill pediatric patients. [PDF]

Nat Med
Rabea F, Aljasmi I, Jain R, Ramaswamy S, Taylor A, Shenbagam S, Chekroun I, Sinha S, El Naofal M, Yaslam S, Alfalasi R, Khadija S, Farag M, AlHajjaj S, Almadhoun F, Sharaf R, Khyriem C, Abulhoul H, Elabd H, Mustafa M, Almarri M, Du Plessis S, AlKhnbashi OS, Majid I, Buhumaid R, Al Suwaidi H, AlAwadhi M, AlKhayat A, Alsheikh-Ali A, Zahraa J, Shankar S, Abou Tayoun A.   +31 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Tumour evolution as ground truth for cancer whole-genome sequencing

Valeriani L, Gandolfi G, Buscaroli E, Davydzenka K, Santacatterina G, Antonello A, Sadr A, Gazziero VA, Milite S, Rivaroli E, Kabanova A, Sanguinetti G, Ansuini A, Egidi L, Cozzini S, Cazzaniga A, Tonon G, Graham T, Sottoriva A, Bergamin R, Calonaci N, Casagrande A, Caravagna G.   +22 more
europepmc   +1 more source

Antifungal Activity of <i>Streptomyces</i> sp. F204 Against Rhizoctonia Solani and Whole-Genome Sequencing and Metabolomic Analysis. [PDF]

J Fungi (Basel)
Shen L, Xue J, Zhu L.
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting. [PDF]

PLoS One
Waggle KD, Griffith MP, Rokes AB, Rangachar Srinivasa V, Nawrocki EM, Ereifej D, Patrick R, Coyle H, Chaudhary S, Raabe NJ, Shutt K, Sundermann AJ, Cooper VS, Harrison LH, Pless LL.   +14 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Whole genome sequencing of measles viruses: the benefit for outbreak investigation, The Netherlands, 2013-2014. [PDF]

Virus Genes
Bodewes R, Maissan C, van de Nes-Reijnen L, Boter M, van den Boom SC, Zwagemaker F, Hahné S, Woudenberg T, Ruijs WLM, Koopmans MPG, Reusken CBEM, de Vries RD, Molenkamp R, de Swart RL, Munnink BO.   +14 more
europepmc   +1 more source

Entropy‐Driven Physical Amplification in Multivalent Biosensing

Advanced Science, EarlyView.
Detecting scarce molecules usually demands enzymatic amplification such as PCR. A statistical‐mechanical theory now reveals a purely physical alternative: distributing a fixed binding strength over more linker arms exponentially lowers the concentration at which multivalent sensors switch on.
Yuhan Peng, Xiuyang Xia, Ran Ni
wiley   +1 more source