Results 251 to 260 of about 3,779,882 (303)

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Telomeric repeat diversity across Nepomorpha (Hemiptera, Heteroptera) revealed by whole-genome sequencing data. [PDF]

Comp Cytogenet
Stoianova D, Karagyan G, Grozeva S.
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Direct whole-genome sequencing of Coxiella burnetii from environmental samples using a two-step selective enrichment approach. [PDF]

PLoS Negl Trop Dis
Bezruchko M, Freylikhman O, Khalilov E, Vakalova E, Kasatkin D, Platova S, Gorokhov I, Saitova A, Karmokov I, Tokarevich N, Polev D, Dedkov V.   +11 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Contributions of whole-genome sequencing to the epidemiological monitoring of <i>Campylobacter</i> spp. in France. [PDF]

Antimicrob Agents Chemother
Jehanne Q, Aptel J, Ducournau A, Bénéjat L, Martin M, Rodriguez C, Lehours P.   +6 more
europepmc   +1 more source

Plasmid-mediated colistin resistance in German Salmonella enterica strains isolated from livestock, food and the environment

, 2019
Borowiak, Maria
core  

Whole genome sequencing

, 2014
Torpdahl, Mia, Löfström, Charlotta, Møller Nielsen, Eva   +2 more
openaire   +1 more source

A Novel Approach to Interrogating Whole Genome Sequencing Data to Optimise Clinical Utility. [PDF]

Mol Genet Genomic Med
Sonner S, McKenna C, Heggarty S, Hamill C, Flanagan C, McKee S, Kerr K, Alhazzaa R, McKnight AJ, Mone F.   +9 more
europepmc   +1 more source

Initial sequencing and comparative analysis of the mouse genome

, 2002
CHIAROMONTE, FRANCESCA, International Mouse Genome Sequencing consortium including, Waterston R   +2 more
core