Results 251 to 260 of about 3,960,512 (303)

Surveillance of antibiotic-resistant bacteria integrating whole genome sequencing and epidemiological information - a global, systematic review, 2012-2023. [PDF]

Antimicrob Resist Infect Control
Reichert F, Perry M, Sandfort M, Haller S, Said D, Eckmanns T, McDermott K, Noake C, Wolff R, Hans JB.   +9 more
europepmc   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Whole-genome sequencing reveals a previously unrecognized measles virus cluster in Burundi. [PDF]

PLoS One
Nzoyikorera N, Nieuwenhuijse DF, Schuele L, Nduwimana C, Ndihokubwayo A, Ihorimbere T, Niyomwungere D, Cassidy H, Boter M, Nibogora C, Molenkamp R, Niyomwungere A, Nizigiyimana D, Uwineza MN, Diawara I, Otani S, Bodewes R, Aarestrup FM, Koopmans M, Nyandwi J, Oude Munnink BB.   +20 more
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Diagnosis Through Whole Genome Sequencing and Care Utilization in Children With Severe Illness.

JAMA Netw Open
Dias JML, More RP, Butler D, Brown J, French CE, Dolling H, Raymond FL, Rowitch DH, Aiken CE.   +8 more
europepmc   +1 more source

Identification and whole-genome sequencing of blood-brain barrier-penetrating Riemerella anatipestifer isolated from chickens and ducks. [PDF]

Poult Sci
Li X, Cheng Y, Dang S, Wang J, Yang K, Guo H, Zhang R, Jiang S, Meng Y.   +8 more
europepmc   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Whole-genome sequencing and molecular characterization of Newcastle disease virus isolates from Kazakhstan. [PDF]

Front Vet Sci
Nurpeisova A, Zheney M, Akshalova P, Ikramkulova F, Begassyl K, Nissanova R, Mamanova S, Serikov M, Ibraim N, Koshkinbay N, Zholdasbekova A, Yoo HS, Kassenov M, Abay Z.   +13 more
europepmc   +1 more source