Results 91 to 100 of about 3,112,739 (313)

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]

, 2019
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A, Horowitz, Mark S, Majchrzak-Hong, Sharon F, Makrides, Maria, Muhlhausler, Beverly S, Ramsden, Christopher E, Taha, Ameer Y, Yuan, Zhi-Xin, Zamora, Daisy   +8 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The proinflammatory activity of recombinant serum amyloid A is not shared by the endogenous protein in the circulation.

, 2010
OBJECTIVE: Elevated serum levels of the acute-phase protein serum amyloid A (SAA) are a marker for active rheumatoid arthritis (RA), and SAA can also be found in the tissues of patients with active RA.
Björkman, Lena, Bylund, Johan, Dahlgren, Claes, Karlsson, Anna, Raynes, John G, Shah, Chandrabala   +5 more
core   +1 more source

Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans [PDF]

, 2018
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a ...
Anderson, J, Harandi, AM, Kratochvil, S, McKay, PF, Olafsdottir, TA, Persson, J, Shattock, RJ, östensson, M   +7 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Analysis of Random Lasing in Human Blood

Biosensors
Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples.
Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, Fernando Lahoz   +5 more
doaj   +1 more source

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

Epigenetics, 2018
Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell ...
John Dou, Rebecca J. Schmidt, Kelly S. Benke, Craig Newschaffer, Irva Hertz-Picciotto, Lisa A. Croen, Ana-Maria Iosif, Janine M. LaSalle, M. Daniele Fallin, Kelly M. Bakulski   +9 more
doaj   +1 more source

Analysis of Archived Residual Newborn Screening Blood Spots After Whole Genome Amplification [PDF]

, 2015
Deidentified newborn screening bloodspot samples (NBS) represent a valuable potential resource for genomic research if impediments to whole exome sequencing of NBS deoxyribonucleic acid (DNA), including the small amount of genomic DNA in NBS material ...
Benstead-Hume, Graeme, Cantarel, Brandi L., Farrell, Andrew, Finnell, Richard H., Lei, Yunping, Reese, Justin, Weaver, Daniel, Zhu, Huiping   +7 more
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source