Results 111 to 120 of about 1,479,555 (266)

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Addressing Economic Insecurities Can Improve Patient‐Reported Outcomes in Lupus

Arthritis Care &Research, EarlyView.
Objective Economic insecurities, such as food, housing, transportation, and financial challenges, are modifiable risk factors and influence patient‐reported outcomes (PROs) in systemic lupus erythematosus (SLE). We examined the following: (1) associations between economic insecurities and PROs, and (2) the impact of screening and addressing economic ...
Jay Patel, Tripti Singh, Meredith Ingersoll, Shelby Gomez, Amanda Weber, Sarah E. Panzer, Sancia Ferguson, Christie M. Bartels, Shivani Garg   +8 more
wiley   +1 more source

Radical footprinting in mammalian whole blood. [PDF]

Nat Commun
Zhao M, Tobin L, Misra SK, Shami AA, Sharma A, Locklar J, Mobarak SA, Luo H, Jones LM, Stewart JA, Sharp JS.   +10 more
europepmc   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Predicting trajectories of illness using RNA velocity of whole blood. [PDF]

Nat Commun
Dunican C, Wilson C, Habgood-Coote D, Paterson S, Noursadeghi M, Moseki R, Stek C, Wilkinson RJ, Agyeman PKA, Beudeker CR, Biesbroek G, von Both U, Brengel-Pesce K, Carrol ED, Coin LJM, D'Souza G, De T, Emonts M, Fidler K, Fink CG, van der Flier M, Georgaki I, Kolberg L, Kolnik M, Kuijpers T, Martinón-Torres F, Mommert-Tripon M, Nichols S, Paulus S, Pokorn M, Pollard AJ, Rivero-Calle I, Rudzate A, Schlapbach LJ, Schweintzger NA, Shen CF, Shrestha S, Tan CD, Tsolia M, Usuf E, van der Velden F, Vermont CL, Voice M, Yeung S, Zavadska D, Zenz W, Wright VJ, Levin M, Herberg J, PERFORM Consortium, Lai RPJ, Meintjes G, Chiu C, Barahona M, Kaforou M, Cunnington AJ.   +55 more
europepmc   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source

Whole blood resuscitation and post-traumatic organ dysfunction in injured children. [PDF]

Transfusion
Feeney EV, Scarmack MA, Furman LM, Spinella PC, Kalinowski AH, Horvat CM, Gaines BA, Leeper CM.   +7 more
europepmc   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

Advanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho, Hyunjae Kim, Seung Eun Yu, Sangmin Lee, Ji Youn Lee, Mi‐Lan Kang, Kang Suk Lee, Young Sik Choi, Hak‐Joon Sung   +8 more
wiley   +1 more source

Psilocin glucuronide in whole blood: a stable and useful biomarker of psilocybin intake. [PDF]

J Anal Toxicol
Bergh MS, Bogen IL, Vevelstad M, Øiestad ÅML.   +3 more
europepmc   +1 more source