Results 131 to 140 of about 5,584,779 (298)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The introduction and implications of the European Blood Alliance practical guidance on implementation of a whole blood programme within a blood service

Zhongguo shuxue zazhi
Whole blood, containing all blood components in physiological proportions, is a preferred resuscitative fluid for patients with severe hemorrhage. The preparation, supply, and clinical use of whole blood are more convenient, safe, and effective, offering
GUO Yongjian, WANG Hongjie
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Whole blood viscosity issues VII: the correlation with leucocytosis and implication on leukapheresis

, 2010
Background: Blood hyperviscosity has been acknowledged to be a complicating factor in polycythaemia and hyperproteinaemia. Hyperleucocytosis has also been implicated in hyperviscosity and may be a basis for therapeutic leukapheresis.
Nwose, Ezekiel Ub, Richards, Ross Stuart
core   +1 more source

Establishment of a rapid and highly sensitive direct-RAA-RDB detection platform: application in non-deletion α-thalassemia

Frontiers in Molecular Biosciences
IntroductionRecombinase-Aided Amplification (RAA) is widely applied in genetic diagnostics owing to its simplicity and speed, making it a primary choice for Point-of-Care Testing (POCT). However, standard protocols require nucleic acid extraction.
Yan Wei, Yilian Zhao, Chao Ye, Mengru Xie, Xiaoxing Zhou, Jinghui Ma, Xingchu Liu, Jilin Qing, Zhizhong Chen   +8 more
doaj   +1 more source

Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke

Existing effective treatments for ischemic stroke restore blood supply to the ischemic region using thrombolysis or mechanical removal of clot. However, it is increasingly recognized that successful removal of occlusive thrombus from the large artery ...
Lillicrap, Thomas P., Bhattarai, Aseem, Garcia-Esperon, Carlos G., Spratt, Neil, Bivard, Andrew, Gyawali, Prajwal   +5 more
core   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Swift and accurate detection of tacrolimus concentration post-organ transplantation using a photonic crystal chip

Nano Research
Tacrolimus (FK506) is a potent immunosuppressant widely used to prevent rejection following organ transplantation. In this study, we employed a photonic crystal microarray-based competitive assay to measure tacrolimus blood concentrations, facilitating ...
Bin Shi, Yingli Li, Zewei Lian, Wenjing Lu, Cui Zhang, Fangwei Wang, Wanheng Liu, Yicong Geng, Xueping Ma, Meng Su   +9 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Label‐Free Single‐Molecule Immunoassay

Advanced Science
Single‐molecule immunoassay is a reliable technique for the detection and quantification of low‐abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research.
Xiaoyan Zhou, Chao Chen, Shuang Zhou, Guangzhong Ma, Mohammad Javad H. N. Chemerkouh, Christine L. H. Snozek, Eric H. Yang, Jiapei Jiang, Brandyn Braswell, Zijian Wan, Xinyu Zhou, Shaopeng Wang   +11 more
doaj   +1 more source