Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson+12 more
wiley +1 more source
Retrospective analysis of whole blood donor demographics at a rural University in India. [PDF]
Singh AK+4 more
europepmc +1 more source
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput+5 more
wiley +1 more source
Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib. [PDF]
Bellocchi C+11 more
europepmc +1 more source
Citrate anticoagulation for extracorporeal circuits: Effects on whole blood coagulation activation and clot formation [PDF]
Calatzis, A.+4 more
core +1 more source
A Vertically‐Stacked Optoelectronic Sensor for Localized Hemodynamics Monitoring
This work introduces a hemodynamics monitoring sensor that features vertically stacked microLEDs and a heterogeneously integrated photodetector. The vertically stacked microLEDs enable localized measurements, and by designing the interoptode distance according to the depth of the target region, this vertically stacked optoelectronic sensor is ...
Taeyeon Lee+9 more
wiley +1 more source
Antimicrobial Peptides Can Facilitate Whole Blood Safety from Bacteria: A Proof of Concept. [PDF]
Chattagul S+3 more
europepmc +1 more source
Measurement of blood loss by means of a whole-body counter. [PDF]
J. M. Holt+3 more
openalex +1 more source
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras+19 more
wiley +1 more source
Bridging the gap: whole blood and plasma in prehospital hemorrhagic shock resuscitation. [PDF]
Levy MJ+3 more
europepmc +1 more source