Results 61 to 70 of about 1,446,856 (268)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Analysis of Random Lasing in Human Blood

Biosensors
Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples.
Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, Fernando Lahoz   +5 more
doaj   +1 more source

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

Epigenetics, 2018
Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell ...
John Dou, Rebecca J. Schmidt, Kelly S. Benke, Craig Newschaffer, Irva Hertz-Picciotto, Lisa A. Croen, Ana-Maria Iosif, Janine M. LaSalle, M. Daniele Fallin, Kelly M. Bakulski   +9 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Whole Blood Method for Assessing the Innate Immune Response in Chickens

Poultry
Innate immunity is considered the first line of immune defense and is typically an unmeasured response. Here we report a method for evaluating the innate immune response in chickens by using whole blood which has been activated by lipopolysaccharide (LPS)
Donald L. Reynolds, E. Barry Simpson, Matthew M. Hille, Beibei Jia   +3 more
doaj   +1 more source

Identification of bacterial and fungal pathogens directly from clinical blood cultures using whole genome sequencing

, 2023
Stephen W. Peterson, Walter Demczuk, Irene Martín, Heather J. Adam, Amrita Bharat, M. R. Mulvey   +5 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography

, 2022
Raymond Fang, Ian Rubinoff, Hao F. Zhang
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

T2Bacteria magnetic resonance assay for the rapid detection of ESKAPEc pathogens directly in whole blood [PDF]

, 2018
Giulia De Angelis, Brunella Posteraro, Elena De Carolis, Giulia Menchinelli, Francesco Franceschi, Mario Tumbarello, Gennaro De Pascale, Teresa Spanu, Maurizio Sanguinetti   +8 more
openalex   +1 more source