Results 51 to 60 of about 43,567 (267)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Prognostic significance of whole blood parameters in patients with spontaneous subarachnoid hemorrhage

Medicine Science, 2020
Subarachnoid hemorrhage (SAH) is an emergency requiring rapid diagnosis and treatment. No marker has yet to be determined, demonstrating the diagnosis and prognosis of SAH. The aim of this study was to retrospectively evaluate the patients diagnosed with
Keziban Ucar Karabulut
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The First Case of the Identification of a Microorganism Directly from Whole Blood Using MALDI-TOF Mass Spectrometry in an Onco-Hematological Pediatric Patient with Bloodstream Infection

Antibiotics
Background: Bloodstream infections affect up to 20% of pediatric cancer patients receiving intensive care, contributing significantly to morbidity and mortality, with infection-related mortality rates reported to be as high as 16%.
Venere Cortazzo, Maria del Carmen Pereyra Boza, Vanessa Tuccio Guarna Assanti, Gianluca Foglietta, Gianluca Vrenna, Marilena Agosta, Elena Chaiter, Martina Rossitto, Barbara Lucignano, Manuela Onori, Valeria Fox, Marco Becilli, Pietro Merli, Filippo Frioni, Carlo Federico Perno, Paola Bernaschi   +15 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Enhancing bloodstream infection diagnostics: a novel filtration and targeted next-generation sequencing approach for precise pathogen identification

Frontiers in Microbiology
Bloodstream infections (BSIs) pose a significant diagnostic challenge, largely due to the limitations of traditional methods such as blood cultures. These methods often yield low positive rates, have lengthy processing times that delay treatment, and are
Ting-Syuan Lin, Ting-Syuan Lin, Ting-Syuan Lin, ZiHao Zhu, ZiHao Zhu, ZiHao Zhu, XiaoHong Lin, Hsi-Yuan Huang, Hsi-Yuan Huang, Hsi-Yuan Huang, Li-Ping Li, Li-Ping Li, Li-Ping Li, Jing Li, Jing Li, Jing Li, Jie Ni, Jie Ni, Jie Ni, PeiZhi Li, LanChun Chen, WeiXin Tang, HuiXin Liu, XiaoLong Se, MingFei Xie, Canling Long, Chih-Min Chiu, Szu-Han Fang, JiaMing Zhao, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, XueTao Yu, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang   +36 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A clinically validated human capillary blood transcriptome test for global systems biology studies

BioTechniques, 2020
To prevent and treat chronic diseases, including cancer, a global application of systems biology is needed. We report here a whole blood transcriptome test that needs only 50 μl of capillary (fingerprick) blood.
Ryan Toma, Nathan Duval, Benjamin Pelle, Matthew M Parks, Vishakh Gopu, Pedro J Torres, Francine R Camacho, Nan Shen, Subha Krishnan, Andrew Hatch, Hal Tily, Ally Perlina, Guruduth Banavar, Momchilo Vuyisich   +13 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source