Results 61 to 70 of about 5,584,779 (298)

Whole-blood leukocyte responsiveness to LPS in critically ill patients.

, 2022
(A) LPS-induced whole blood leukocyte cytokine production in critically ill patients on the first day after admission (n = 77) stratified according to quartiles of TNF-α production capacity (normal, slightly reduced, moderately reduced, and strongly ...
Maryse A. Wiewel (13149803), Lonneke A. van Vught (9118039), Marcus J. Schultz (7586684), Xanthe Brands (8802716), Arie J. Hoogendijk (9118033), Brendon P. Scicluna (8802731), Tom van der Poll (33907), René Lutter (3407615), Fabrice Uhel (3682579)   +8 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data

Frontiers in Genetics, 2016
DNA methylation levels vary markedly by cell-type makeup of a sample. Understanding these differences and estimating the cell-type makeup of a sample is an important aspect of studying DNA methylation.
Lindsay L Waite, Lindsay L Waite, Benjamin eWeaver, Kenneth eDay, Xinrui eLi, Kevin eRoberts, Andrew W Gibson, Jeffrey C Edberg, Robert P Kimberly, Devin M Absher, Hemant K Tiwari   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo

Frontiers in Pharmacology, 2020
RationaleThe development of inhibitors of microsomal prostaglandin (PG)E2 synthase-1 (mPGES-1) was driven by the promise of attaining antiinflammatory agents with a safe cardiovascular profile because of the possible diversion of the accumulated ...
Luigia Di Francesco, Annalisa Bruno, Emanuela Ricciotti, Stefania Tacconelli, Melania Dovizio, Paloma Guillem-Llobat, Maria Alessandra Alisi, Beatrice Garrone, Isabella Coletta, Giorgina Mangano, Claudio Milanese, Garret A. FitzGerald, Paola Patrignani   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Stability of Cardiac Troponin-I in Whole Blood and Plasma in Patients with Acute Myocardial Infarction

İstanbul Medical Journal, 2021
Introduction:In this study, we aimed to investigate the short-term stability and variability of cardiac troponin T (cTnI) in ethylenediamine tetraacetic acid (EDTA) whole blood, heparinized whole blood, and EDTA plasma.Methods:Thirteen patients with ...
Umut Karabulut, Dilay Karabulut, Pınar Kasapoğlu, Serkan Yazan, Mehmet Ertürk, Murat Koşer, Nilgün Işıksaçan   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Whole blood optical biosensor [PDF]

Biosensors and Bioelectronics, 2007
The future of rapid point-of-care diagnostics depends on the development of cheap, noncomplex, and easily integrated systems to analyze biological samples directly from the patient (e.g. blood, urine, and saliva). A key concern in diagnostic biosensing is signal differentiation between non-specifically bound material and the specific capture of target ...
Lisa M, Bonanno, Lisa A, DeLouise
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source