Results 31 to 40 of about 43,567 (267)

Impact of the COVID-19 Pandemic on Blood Supply

Philippine Journal of Pathology, 2023
Objective. The study aimed to determine the impact of the COVID-19 pandemic on local blood supply management in the Davao Region, Philippines from 2019 to 2021 through the analysis of trends in blood supply in Davao Region, Philippines.
Johnmerson Yap, Ma. Theresa Fedoc-Minguito   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Whole blood: back to the future [PDF]

Transfusion, 2019
See article on page 3468–3477, in this ...
Nancy Rebecca Haley, John R. Hess
openaire   +2 more sources

Biomarker discovery for non-invasive diagnosis of inflammatory bowel disease using blood transcriptomics

Frontiers in Immunology
IntroductionColonoscopy remains the gold standard for diagnosing inflammatory bowel disease (IBD) even though it is an invasive and costly procedure.
Mohammad Hossein Derakhshan Nazari, Mahsa Ghorbaninejad, Shabnam Shahrokh, Anna Meyfour   +3 more
doaj   +1 more source

Whole blood transfusion in small animals: indications and effects

Anais da Academia Brasileira de Ciências, 2011
Transfusion therapy is a major resource that can improve the patient's capability to overcome the underlying disease. However, the effects of whole blood infusion, and how they affect the patient's outcome, are not yet clear.
Luís F Godinho-Cunha, Rui M. R. F Ferreira, Ana C Silvestre-Ferreira   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data

Frontiers in Genetics, 2016
DNA methylation levels vary markedly by cell-type makeup of a sample. Understanding these differences and estimating the cell-type makeup of a sample is an important aspect of studying DNA methylation.
Lindsay L Waite, Lindsay L Waite, Benjamin eWeaver, Kenneth eDay, Xinrui eLi, Kevin eRoberts, Andrew W Gibson, Jeffrey C Edberg, Robert P Kimberly, Devin M Absher, Hemant K Tiwari   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo

Frontiers in Pharmacology, 2020
RationaleThe development of inhibitors of microsomal prostaglandin (PG)E2 synthase-1 (mPGES-1) was driven by the promise of attaining antiinflammatory agents with a safe cardiovascular profile because of the possible diversion of the accumulated ...
Luigia Di Francesco, Annalisa Bruno, Emanuela Ricciotti, Stefania Tacconelli, Melania Dovizio, Paloma Guillem-Llobat, Maria Alessandra Alisi, Beatrice Garrone, Isabella Coletta, Giorgina Mangano, Claudio Milanese, Garret A. FitzGerald, Paola Patrignani   +12 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source