Results 81 to 90 of about 1,446,856 (268)

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Simplifying lymphocyte culture and the deoxyuridine suppression test by using whole blood (0.1 mL) instead of separated lymphocytes. [PDF]

, 1980
K C Das, C Manusselis, V Herbert
openalex   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα

Frontiers in Pharmacology
BackgroundPPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of
Alessandra Ammazzalorso, Stefania Tacconelli, Annalisa Contursi, Ulrika Hofling, Carmen Cerchia, Sara Di Berardino, Alessandra De Michele, Rosa Amoroso, Antonio Lavecchia, Paola Patrignani   +9 more
doaj   +1 more source

Pengaruh Lama Penyimpanan Kantong Darah terhadap Kadar Hemoglobin pada Komponen Whole Blood di Unit Donor Darah PMI Kota Palangka Raya

, 2021
Windya Nazmatur Rahmah, Adinda Chairunnissa   +1 more
openalex   +2 more sources

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Comparison of DNA extraction efficiency between two commercial kits on whole blood, swab, and plasma samples

Vietnam Journal of Science, Technology and Engineering
Whole blood, swab, and plasma samples are widely used in molecular biology testing in Vietnam. However, most DNA extraction kits currently in use are imported and rely on silica column technology, which can be challenging to integrate into automated or ...
Minh Quan Hoang, Huu An Nguyen, Bich Huong Bui, Thuy Quynh Nguyen, Thuy Ngan Nguyen, Thi Phuong Nguyen, Thi Hoi Le, Tien Dung Pham   +7 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Reactivity of HLADR antibody manifests expression of surface MHC II molecules on peripheral blood T lymphocytes in new world monkeys

Immunity, Inflammation and Disease
Background Major histocompatibility complex (MHC) class II molecules expressed on B cells, monocytes and dendritic cells present processed peptides to CD4+ T cells as one of the mechanisms to combat infection and inflammation.
Sriram Chitta, Bharti P. Nehete, Ashley B. Delise, Joe H. Simmons, Pramod N. Nehete   +4 more
doaj   +1 more source

Assessment of Fatty Acid Concentrations Among Blood Matrices

Metabolites
Background/Objectives: Fatty acids, the building blocks of lipids, contribute to numerous crucial life processes and are implicated in numerous disease pathologies.
Ysphaneendra Mallimoggala, Monalisa Biswas, Leslie Edward S. Lewis, Vijetha Shenoy Belle, Arjun Asok, Varashree Bolar Suryakanth   +5 more
doaj   +1 more source