Results 91 to 100 of about 2,882,218 (304)
, 2014 SNPs and indels identified by low-coverage whole-genome sequencing (WGS-4x) and whole exome sequencing (WES) amongst South Asians.
James Abbott (614010) +36 more
core +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Whole Exome Sequencing of Chronic Myeloid Leukemia Patients
Iranian Journal of Public Health, 2016 Background: Previous studies have shown that leukemogenic chromosomal translocations, including fusions between Break point Cluster Region (BCR) and Abelson (ABL) are present in the peripheral blood of healthy individuals.
Shaghayegh SABRI +2 more
doaj
Summary of sequencing results from whole genome and exome sequencing data.
, 2014 Summary of sequencing results from whole genome and exome sequencing data.
Pongsathorn Chaiyasap (580996) +5 more
core +1 more source
The GENCODE exome: sequencing the complete human exome [PDF]
, 2011 Sequencing the coding regions, the exome, of the human genome is one of the major current strategies to identify low frequency and rare variants associated with human disease traits.
Palta, P +42 more
core +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Whole‐Exome Sequencing Study of Extreme Phenotypes of NAFLD
Hepatology Communications, 2018 Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatitis (NASH ...
Sarah E. Kleinstein +6 more
doaj +1 more source
Top ten most strongly associated individual variants from whole exome sequencing.
, 2022 Top ten most strongly associated individual variants from whole exome sequencing.
Pingxing Xie (290131) +9 more
core +1 more source
Advanced Science, EarlyView.The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian +14 more
wiley +1 more source
Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance
Advanced Science, EarlyView.COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu +12 more
wiley +1 more source