Results 11 to 20 of about 3,587,142 (311)
Whole genome sequencing analysis of
BMC Genomics, 2012 Background Malaria caused by Plasmodium vivax is an experimentally neglected severe disease with a substantial burden on human health. Because of technical limitations, little is known about the biology of this important human pathogen.
Bright A +8 more
doaj +6 more sources
Whole Genome Sequencing in Pharmacogenomics [PDF]
Frontiers in Pharmacology, 2015 -
George P Patrinos, Theodora eKatsila
doaj +3 more sources
Translating whole‐genome doubling into precision medicine in cancer [PDF]
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +2 more sources
Principles of Whole-Genome Amplification
, 2015 Modern molecular biology relies on large amounts of high-quality genomic DNA. However, in a number of clinical or biological applications this requirement cannot be met, as starting material is either limited (e.g., preimplantation genetic diagnosis (PGD) or analysis of minimal residual cancer) or of insufficient quality (e.g., formalin-fixed paraffin ...
Zbigniew Tadeusz, Czyz +2 more
openaire +3 more sources
Practical Neurology, 2021 The costs of whole-genome sequencing have rapidly decreased, and it is being increasingly deployed in large-scale clinical research projects and introduced into routine clinical care. This will lead to rapid diagnoses for patients with genetic disease but also introduces uncertainty because of the diversity of human genomes and the potential ...
Huw R Morris, Henry Houlden, James Polke
openaire +3 more sources
Forensic Applications of Whole Genome Amplification [PDF]
, 2011 Whole genome amplification (WGA) has been touted as a possible technique to augment fragment analysis of STRs in amplifying low-levels of DNA recovered from crime scenes or items.
Williams, Graham
core +3 more sources
Alignment of whole genomes [PDF]
Nucleic Acids Research, 1999 A new system for aligning whole genome sequences is described. Using an efficient data structure called a suffix tree, the system is able to rapidly align sequences containing millions of nucleotides. Its use is demonstrated on two strains of Mycoplasma tuberculosis, on two less similar species of Mycoplasma bacteria and on two syntenic sequences from ...
A L, Delcher +5 more
openaire +2 more sources
Nature Reviews Genetics, 2005 Gene patenting is now a familiar commercial practice, but there is little awareness that several patents claim ownership of the complete genome sequence of a prokaryote or virus. When these patents are analysed and compared to those for other biological entities, it becomes clear that genome patents seek to exploit the genome as an information base and
O'Malley, Maureen A. +2 more
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Deterministic whole-genome amplification of single cells
, 2022 S.69-86This chapter describes a single-cell whole genome amplification method (WGA) that has been originally published under the name "Single Cell Comparative Genomic Hybridization (SCOMP)" (Klein et al., Proc Natl Acad Sci U S A 96(8):4494-4499, 1999 ...
Czyz, Zbigniew Tadeusz +1 more
core +1 more source
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma [PDF]
npj Precision Oncology, 2018 AbstractEccrine porocarcinomas (EPs) are rare malignant tumours of the intraepidermic sweat gland duct and most often arise from benign eccrine poromas. Some recurrent somatic genomic events have been identified in these malignancies, but very little is known about the complexity of their molecular pathophysiology.
My Linh Thibodeau +20 more
openaire +2 more sources