Results 201 to 210 of about 157,765 (267)

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Variation in nuclear genome size in a freshwater snail model system featuring a recent whole-genome duplication. [PDF]

R Soc Open Sci
Neiman M, Pichler M, Haase M, Lamatsch DK.   +3 more
europepmc   +1 more source

From the archives: BETL, gamma, alpha-an unexpected transporter mediating sucrose transfer in maize, innovation by whole-genome duplication, and cooperative DNA binding by Opaque2. [PDF]

Plant Cell, 2023
Artur MAS.
europepmc   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Resolving phylogenetic conflicts in Pandanales: the dual roles of gene flow and whole-genome duplication. [PDF]

Front Plant Sci
Shi T, He J.
europepmc   +1 more source

Whole-genome Duplication Reshaped Adaptive Evolution in A Relict Plant Species, Cyclocarya paliurus. [PDF]

Genomics Proteomics Bioinformatics, 2023
Qu Y, Shang X, Zeng Z, Yu Y, Bian G, Wang W, Liu L, Tian L, Zhang S, Wang Q, Xie D, Chen X, Liao Z, Wang Y, Qin J, Yang W, Sun C, Fu X, Zhang X, Fang S.   +19 more
europepmc   +1 more source

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

Investigating the Impact of Whole-Genome Duplication on Transposable Element Evolution in Teleost Fishes. [PDF]

Genome Biol Evol
Mallik R, Wcisel DJ, Near TJ, Yoder JA, Dornburg A.   +4 more
europepmc   +1 more source

A New Hope: A Hermaphroditic Nematode Enables Analysis of a Recent Whole Genome Duplication Event. [PDF]

Genome Biol Evol, 2022
Wighard SS, Athanasouli M, Witte H, Rödelsperger C, Sommer RJ.   +4 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source