Results 131 to 140 of about 1,170,509 (350)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation

Science Translational Medicine, 2019
Automated phenotyping and interpretation of rapid whole-genome sequencing improve time to diagnosis of genetic diseases in hospitalized children. A streamlined genetic diagnosis pipeline When treating seriously ill children, time is of the essence. Clark
Michelle M. Clark, Amber Hildreth, Serge Batalov, Yan Ding, S. Chowdhury, K. Watkins, Katarzyna A Ellsworth, Brandon Camp, C. Kint, C. Yacoubian, L. Farnaes, M. Bainbridge, Curtis Beebe, Joshua J. A. Braun, Margaret Bray, Jeanne Carroll, Julie A. Cakici, Sara A. Caylor, C. Clarke, Mitchell P. Creed, J. Friedman, A. Frith, Richard Gain, Mary Gaughran, Shauna George, S. Gilmer, J. Gleeson, Jeremy Gore, Haiying Grunenwald, Raymond L Hovey, Marie L Janes, Kejia Lin, P. McDonagh, K. McBride, Patrick Mulrooney, S. Nahas, D. Oh, A. Oriol, L. Puckett, Z. Rady, M. G. Reese, J. Ryu, Lisa Salz, E. Sanford, Lawrence Stewart, Nathaly M. Sweeney, M. Tokita, L. Van Der Kraan, S. White, Kristen M. Wigby, Brett Williams, Terence Wong, M. Wright, Catherine Yamada, P. Schols, J. Reynders, K. Hall, D. Dimmock, N. Veeraraghavan, Thomas Defay, S. Kingsmore   +60 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Genomic insights from whole genome sequencing of four clonal outbreak Campylobacter jejuni assessed within the global C. jejuni population [PDF]

, 2016
Clifford G. Clark, Chrystal Berry, Matthew G. Walker, Aaron Petkau, Dillon Barker, Cai Guan, Aleisha Reimer, Eduardo N. Taboada   +7 more
openalex   +1 more source

Sensitive Long-Indel-Aware Alignment of Sequencing Reads

, 2013
The tremdendous advances in high-throughput sequencing technologies have made population-scale sequencing as performed in the 1000 Genomes project and the Genome of the Netherlands project possible.
Marschall, Tobias, Schönhuth, Alexander
core  

Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction

Circulation, 2019
Background: The relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score (cumulative impact of many common variants) pathways for early-onset myocardial infarction remain ...
A. Khera, M. Chaffin, S. Zekavat, Ryan L. Collins, C. Roselli, P. Natarajan, J. Lichtman, G. D'Onofrio, J. Mattera, R. Dreyer, J. Spertus, K. Taylor, B. Psaty, S. Rich, W. Post, N. Gupta, S. Gabriel, E. Lander, Y. Ida Chen, M. Talkowski, J. Rotter, H. Krumholz, S. Kathiresan   +22 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Optimal sequencing depth design for whole genome re-sequencing in pigs

BMC Bioinformatics, 2019
Background As whole-genome sequencing is becoming a routine technique, it is important to identify a cost-effective depth of sequencing for such studies.
Yifan Jiang, Yao Jiang, Sheng Wang, Qin Zhang, Xiangdong Ding   +4 more
doaj   +1 more source

From Clinical Specimen to Whole Genome Sequencing of A(H3N2) Influenza Viruses: A Fast and Reliable High-Throughput Protocol [PDF]

, 2022
Cristina Galli, Erika Ebranati, Laura Pellegrinelli, Martina Airoldi, Carla Veo, Carla Della Ventura, Arlinda Seiti, S. Binda, Massimo Galli, Gianguglielmo Zehender, Elena Pariani   +10 more
openalex   +1 more source

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing

J. Comput. Biol., 2012
The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome ...
A. Bankevich, S. Nurk, D. Antipov, A. Gurevich, M. Dvorkin, Alexander S. Kulikov, Valery M. Lesin, S. Nikolenko, Son K. Pham, Andrey D. Prjibelski, A. Pyshkin, Alexander Sirotkin, Nikolay Vyahhi, G. Tesler, M. Alekseyev, P. Pevzner   +15 more
semanticscholar   +1 more source