Results 141 to 150 of about 567,748 (308)

Integrating patient and whole-genome sequencing data to provide insights into the epidemiology of seasonal influenza A(H3N2) viruses

, 2017
E. J. C. Goldstein, William T. Harvey, Gavin S. Wilkie, Samantha J. Shepherd, Alasdair Maclean, Pablo R. Murcia, Rory Gunson   +6 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

MetaSTAARlite: an all-in-one tool for biobank-scale whole-genome sequencing meta-analysis. [PDF]

Nat Comput Sci
Kumarasinghe Y, Williams J, Yuan Y, Wang W, Dias JA, Zhang H, Li Z, Li X.   +7 more
europepmc   +1 more source

Additional file 8 of Characterization and whole genome sequencing of a novel strain of Bergeyella cardium related to infective endocarditis

, 2020
Hongwei Pan, Wei Li, Enhua Sun, Yi Zhang
openalex   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Genomics in Equine MEED: Whole-Genome Sequencing and Target Mutation Identification. [PDF]

Animals (Basel)
Tanner K, Mays M, Nguyen TA, Lugo T.
europepmc   +1 more source

Whole genome sequencing of haploids in Arabidopsis thaliana

, 2020
Zhong, Yu, Chen, Baojian, Li, Mengran, Wang, Dong, Jiao, Yanyan, Qi, Xiaolong, Wang, Min, Liu, Zongkai, Chen, Chen, Wang, Yuwen, Chen, Ming, Li, Jinlong, Xiao, Zijian, Cheng, Dehe, Liu, Wenxin, Boutilier, K.A., Liu, Chenxu, Chen, Shaojiang   +17 more
openalex   +1 more source

Additional file 2 of Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

, 2020
Bibi Slingerland, Martine De Vos, Willeke Bras, René F. Kornelisse, Dieter De Coninck, Alex van Belkum, Irwin Reiss, Wil H. F. Goessens, Corné H. W. Klaassen, Nelianne J. Verkaik   +9 more
openalex   +1 more source

Additional file 4 of Genotype diversity of brucellosis agents isolated from humans and animals in Greece based on whole-genome sequencing

, 2023
Hanka Brangsch, Vassilios Sandalakis, Maria Babetsa, Evridiki Boukouvala, Artemisia Ntoula, Eirini Makridaki, Athanasia Christidou, Anna Psaroulaki, Kadir Akar, Sevil Erdenliğ Gürbi̇lek, Tariq Jamil, Falk Melzer, Heinrich Neubauer, Gamal Wareth   +13 more
openalex   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source