Results 221 to 230 of about 533,077 (310)

Tracking ongoing chromosomal instability using single-cell whole-genome sequencing

Hernando B, Chaves-Urbano B, Escobar-Rey M, Torres M, Cadiz A, Fernandez-Sanroman A, Barrambana S, Lechuga CG, Guerra C, Barbacid M, Gómez-Sánchez D, Sanchez-Vega F, Razavi P, Garcia-Perez M, Santamaria PG, Macintyre G.   +15 more
europepmc   +1 more source

Whole-genome sequencing of 490,640 UK Biobank participants. [PDF]

Nature
UK Biobank Whole-Genome Sequencing Consortium.
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

A Deep Autoencoder Compression-Based Genomic Prediction Method for Whole-Genome Sequencing Data. [PDF]

Biology (Basel)
Song H, Dong T, Wang W, Yan X, Geng C, Bai S, Hu H.   +6 more
europepmc   +1 more source

Peer Review #1 of "BALSA: integrated secondary analysis for whole-genome and whole-exome sequencing, accelerated by GPU (v0.1)"

, 2014
J Zook
openalex   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Implementing whole genome sequencing for foodborne pathogen surveillance: insights and recommendations based on expert experiences. [PDF]

Front Microbiol
Pijnacker R, van den Beld M, Ullrich A, Ceyssens PJ, van Cauteren D, Jore S, Nielsen EM, Ethelberg S, Morabito S, Lanzl M, Franz E.   +10 more
europepmc   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data. [PDF]

Comput Struct Biotechnol J
Wang Y, Liu T, He Y, Tang Y, Tan P, Huang L, Huang D, Wen T, Shao L, Wang J, Wang Y, Han Z.   +11 more
europepmc   +1 more source

Whole Genome Shotgun Sequencing [PDF]

, 2006
openaire   +1 more source