Results 51 to 60 of about 905,467 (298)
PennCNV in whole-genome sequencing data
BMC Bioinformatics, 2017 Background The use of high-throughput sequencing data has improved the results of genomic analysis due to the resolution of mapping algorithms. Although several tools for copy-number variation calling in whole genome sequencing have been published, the ...
Leandro de Araújo Lima, Kai Wang
doaj +1 more source
Whole-genome sequencing analysis of semi-supercentenarians
eLife, 2021 Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases.
Paolo Garagnani +34 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
VirusesCoronavirus disease 2019 (COVID-19) has been associated with a significant fatality rate and persistent evolution in immunocompromised patients. In this prospective study, we aimed to determine the duration of excretion of severe acute respiratory ...
Asma Themlaoui +10 more
doaj +1 more source
Whole-genome sequencing data of Kazakh individuals
BMC Research Notes, 2021 Objectives Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today is the multi-ethnic country with ...
Ulykbek Kairov +10 more
doaj +1 more source
An efficient approach to BAC based assembly of complex genomes [PDF]
, 2016 Background: There has been an exponential growth in the number of genome sequencing projects since the introduction of next generation DNA sequencing technologies.
A D’Hont +48 more
core +5 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
ForestQC: Quality control on genetic variants from next-generation sequencing data using random forest. [PDF]
, 2019 Next-generation sequencing technology (NGS) enables the discovery of nearly all genetic variants present in a genome. A subset of these variants, however, may have poor sequencing quality due to limitations in NGS or variant callers.
Coppola, Giovanni +6 more
core +1 more source
Future of whole genome sequencing [PDF]
Journal of Paediatrics and Child Health, 2014 The era of genomic medicine, anticipated since the completion of the Human Genome Project in 2003, is now upon us. Before long, genomic information will be an integral part of the medical record, and paediatricians will be able to interrogate these data for a range of purposes: to make a diagnosis in a sick child, to diagnose or exclude a rare genetic ...
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source