Results 61 to 70 of about 3,777,350 (304)

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Nature Communications, 2020
With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes
Matthew H. Bailey, William U. Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Gordon Saksena, Kyle Ellrott, Michael C. Wendl, David A. Wheeler, Gad Getz, Jared T. Simpson, Mark B. Gerstein, Li Ding, PCAWG Consortium   +20 more
doaj   +1 more source

Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus [PDF]

, 2010
Background: The size and repetitive nature of the Rhipicephalus microplus genome makes obtaining a full genome sequence fiscally and technically problematic. To selectively obtain gene-enriched regions of this tick's genome, Cot filtration was performed,
Matthew Bellgard, Peterson, D., Appolinaire Djikeng, Nene, Vishvanath M., Felix D Guerrero, Guerrero, F.D., Caler, E., Moolhuijzen, Paula, Vishvanath M Nene, Elisabet Caler, Djikeng, Appolinaire, Nene, V.M., Paula Moolhuijzen, Moolhuijzen, P., Shelby Bidwell, Bellgard, M., Daniel G Peterson, Nene, V., Djikeng, A., Guerrero, F., Peterson, D.G., Bidwell, S.   +21 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Virological Aspects of COVID-19 in Patients with Hematological Malignancies: Duration of Viral Shedding and Genetic Analysis

Viruses
Coronavirus disease 2019 (COVID-19) has been associated with a significant fatality rate and persistent evolution in immunocompromised patients. In this prospective study, we aimed to determine the duration of excretion of severe acute respiratory ...
Asma Themlaoui, Massimo Ancora, Kais Ghedira, Yosra Mhalla, Manel Hamdoun, Maroua Bahri, Lamia Aissaoui, Raihane Ben Lakhal, Adriano Di Pasquale, Cesare Camma, Olfa Bahri   +10 more
doaj   +1 more source

Whole Genome Sequencing

, 2023
Virilizer (Vir), first isolated from Drosophila melanogaster, plays a role in sex determination. In humans, its homologue and METTL3 are involved in N6-adenosine methylation (m6A) writing. As m6A of mRNA is an important process in most eukaryotes, it is very important to understand its role and the status of factors accompanying this modification ...
openaire   +2 more sources

Algorithms for whole genome shotgun sequencing [PDF]

Proceedings of the third annual international conference on Computational molecular biology, 1999
A monumental achievement in the history of science, the sequencing of the entire human genome, will soon be reached. The Human Genome Project (HGP) has been working toward this goal since 1990 using a two-tiered strategy. Recently it was proposed that using a whole-genome shotgun approach to sequence the genome would be faster and less costly.
Eric L. Anson, Eugene W. Myers
openaire   +2 more sources

Whole genome sequencing in families with oligodontia

Oral Diseases, 2023
Abstract Background/Objectives Tooth agenesis (TA) is among the most common malformations in humans. Although several causative mutations have been described, the genetic cause often remains elusive. Here, we test whether whole genome sequencing (WGS) could bridge this diagnostic gap.
Janna Mitscherling, Henrike L. Sczakiel, Olga Kiskemper‐Nestorjuk, Sibylle Winterhalter, Stefan Mundlos, Theodosia Bartzela, Martin A. Mensah   +6 more
openaire   +3 more sources

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing [PDF]

, 2012
BACKGROUND: Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod ...
Spooner Paul R, Ulrich Certa, Pelle, R., Richard P Bishop, Ebeling, M., Pelle Roger, Lucy Poveda, Roger Pelle, Küng, Erich, Morzaria, S., Henson, Sonal, Morzaria, S.P., Erich Küng, Bishop, Richard P., Daubenberger, C.A., Daubenberger, Claudia A., Certa, U., Spooner, Paul R, Poveda, Lucy, Paul R Spooner, Poveda, L., Ebeling, Martin, Certa, Ulrich, Claudia A Daubenberger, Spooner, P.R., Weihong Qi, Sonal Henson, Bishop Richard P, Spooner, Paul R., Certa Ulrich, Henson Sonal, Henson, S., Morzaria Subhash, Qi Weihong, Poveda Lucy, Subhash Morzaria, Bishop, R. P., Spooner, P. R., Kung, E., Pelle, Roger, Ebeling Martin, Küng Erich, Daubenberger Claudia A, Morzaria, Subhash, Daubenberger, C. A., Bishop, Richard P, Martin Ebeling, Qi, W., Qi, Weihong, Daubenberger, Claudia A   +49 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Whole-Genome Sequencing Redefines Shewanella Taxonomy

Frontiers in Microbiology, 2019
The genus Shewanella encompasses a diverse group of Gram negative, primarily aquatic bacteria with a remarkable ecological relevance, an outstanding set of metabolic features and an emergent clinical importance.
Kaisa Thorell, Jan P. Meier-Kolthoff, Åsa Sjöling, Alberto J. Martín-Rodríguez   +3 more
doaj   +1 more source