Results 91 to 100 of about 933,712 (305)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

FACTORS AFFECTING U.S. DEMAND FOR REDUCED-FAT FLUID MILK [PDF]

U.S. fluid milk consumption has changed dramatically since the early 1970s. Whole milk accounted for over 81% of commercial fluid milk disappearance in 1970. By 1993, this percentage was less than 39%.
Gould, Brian W.
core   +1 more source

Effects of Feeding Whole Cottonseed on Composition of Milk

Journal of Dairy Science, 1985
Complete mixed diets containing 0, 10, 15, or 20% whole cottonseed were fed to 12 cows in a 4 X 4 Latin square design. Cows were assigned to the Latin square by production status resulting in one square each for cows in early first lactation and older cows either in early or late lactation. Diets were fed for ad libitum intake, and periods were 21 days.
E J, DePeters, S J, Taylor, A A, Franke, A, Aguirre   +3 more
openaire   +2 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Performance and development of gastric compartments of calves fed with cheese whey and transition milk

Ciência Rural
: This study aimed to evaluate whether cheese whey associated with transitional milk or not, could serve as a suitable alternative to whole milk for calf rearing.
Maria Vivianne Freitas Gomes de Miranda, Michel Raony Paiva Teixeira de Morais, Renata Nayhara de Lima, Hélia Maria de Souza Leite, Ana Paula Pinheiro de Assis, Tiago da Silva Teófilo, José Domingues Fontenele Neto, Patrícia de Oliveira Lima   +7 more
doaj   +1 more source

RETAIL DEMAND FOR WHOLE VS. LOW-FAT MILK: NEW PERSPECTIVES ON LOSS LEADER PRICING [PDF]

This analysis employed retail scanner data to investigate the demand for fluid mild differentiated by fat content. All own-price elasticities were significant and negative.
Green, Geoffrey M., Park, John L.
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

INFLUÊNCIA DA GORDURA DO LEITE BOVINO E CAPRINO NA RESISTÊNCIA DO Mycobacterium fortuitum À PASTEURIZAÇÃO LENTA

Ciência Animal Brasileira, 2016
This study aimed to show the effect of goat and bovine milk fat on thermal resistance of Mycobacterium fortuitum. Milk samples were divided into two portions, whole and skimmed, each part was inoculated with M. fortuitum and then distributed in tubes for
Karina Ramirez Starikoff, Érika Junko Nishimoto, Fernando Ferreira, Simone Carvalho Balian, Evelise Oliveira Telles   +4 more
doaj   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

MILK REPLACER USE IN SUBSTITUTION OF WHOLE MILK ON THE PERFORMANCE OF HOLSTEIN CALVES DURING GROWING PHASE

Ciência Animal Brasileira, 2015
The objective of this study was to evaluate the biological efficiency of the milk replacer in the substitution of whole milk for calves at the first months of age and at rearing fase. This study was conducted in Universidade Tecnológica Federal do Paraná
Bruna Boito, Luis Fernando Glasenapp de Menezes, Magnos Fernando Ziech, Fernando Kuss, Eduardo Lisbinski, Andréia Fiorelli   +5 more
doaj