Results 151 to 160 of about 85,872 (249)

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Meta-analysis of whole slide imaging diagnostic accuracy in dermatopathology

Journal of Pathology Informatics
Fang Bian, Xiao Zhou
doaj   +1 more source

Whole Slide Imaging (WSI) in Pathology: Emerging Trends and Future Applications in Clinical Diagnostics, Medical Education, and Pathology. [PDF]

Iran J Pathol
Masjoodi S, Anbardar MH, Shokripour M, Omidifar N.   +3 more
europepmc   +1 more source

Whole slide imaging-based deep learning to predict the treatment response of patients with non-small cell lung cancer. [PDF]

Quant Imaging Med Surg, 2023
Pan Y, Sheng W, Shi L, Jing D, Jiang W, Chen JC, Wang H, Qiu J.   +7 more
europepmc   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Evaluating whole slide imaging: A working group opportunity

Journal of Pathology Informatics, 2015
Darren Treanor, Brandon D Gallas, Marios A Gavrielides, Stephen M Hewitt   +3 more
doaj  

Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging. [PDF]

NPJ Precis Oncol
Feng X, Yin W, Ye Q, Chi Y, Wen H, Sun Y, Zheng J, Wang Q, Wang Q, Zhao M, Yuan L, Xu Q, Su D, Zhou X.   +13 more
europepmc   +1 more source

Whole-slide imaging and a Fiji-based image analysis workflow of immunohistochemistry staining of pancreatic islets. [PDF]

MethodsX, 2022
Buckels EJ, Ross JM, Phua HH, Bloomfield FH, Jaquiery AL.   +4 more
europepmc   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

GJFocuser: a Gaussian difference and joint learning-based autofocus method for whole slide imaging. [PDF]

Biomed Opt Express
Chen W, Li C, Huang ZL, Wang Z.
europepmc   +1 more source