Results 101 to 110 of about 100,051 (310)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Restoration of Wholeness [PDF]
Integral Review, 2015 Wholeness is an innate state, a quality which is lost with our exposure to the world. Our life is spent in efforts to restore the state of wholeness in us. The world takes from us our tranquility and balance. Yet it is only from this giving of us that we
Karabi Sen
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
[Review of] Jamaica Kincaid. Annie John [PDF]
, 1990 Annie John, even though set in the West Indies and about a black Caribbean girl, is a work whose universally felt experience goes beyond allowing the novel to be neatly categorized as a piece of ethnic or women\u27s writing.
McNeil, Elizabeth A.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
“SHINING WITH SOUND IN THE UNTRANSLATABLE DARK”—REBECCA ELSON’S POETRY OF COSMIC WISDOM
Studia Universitatis Babeş-Bolyai. Philologia“Shining with sound in the untranslatable dark”—Rebecca Elson’s Poetry of Cosmic Wisdom. Despite having left us only a small body of verse, collected in the posthumously published A Responsibility to Awe (2001), Montreal-born astrophysicist and poet ...
Octavian MORE
doaj +1 more source
The importance of the general system theory for the modern world [PDF]
Trendovi u Poslovanju, 2019 The paper explores General Systems Theory and its methodology. The historical development of the thought of wholeness is presented at the beginning, reflecting on philosophical attitudes that indicated the importance of the whole in relation to the parts.
Šijan Aleksandar +2 more
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source