Results 111 to 120 of about 100,051 (310)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Ethics, Philosophy and the Environment [PDF]
, 2018 Educated people everywhere now acknowledge that ecological destruction is threatening the future of civilization. While philosophers have concerned themselves with environmental problems, they appear to offer little to deal with this crisis. Despite this,
Gare, Arran
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Quantum, consciousness and panpsychism: a solution to the hard problem [PDF]
, 2004 We analyze the results and implications of the combination of quantum and consciousness in terms of the recent QSC analysis. The quantum effect of consciousness is first explored. We show that the consciousness of the observer can help to distinguish the
Gao, Mr Shan
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
One flesh: in the Old and New Testaments [PDF]
, 1979 Genesis 1-11. Although much has been written on sexuality and marriage from the perspective of the Old and New Testaments, little attention has been given to what is perhaps the most engaging and elusive expression relating to the whole topic, namely ...
Stuhlmiller, Wayne J. H.
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Menorah Review (No. 64, Winter/Spring, 2006) [PDF]
, 2006 A Poem by Richard E. Sherwin -- An Exceptional Collection -- Author\u27s Reflections -- Hebrew Literature: Translated and Discussed -- Jewish Humor and Jewish Faith -- Reading Writing -- The Uniqueness of American Judaism -- Noteworthy ...
core +1 more source