Results 111 to 120 of about 4,374,159 (298)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Touristification du surf au Québec

Téoros
For several years, surfing has become a flagship product allowing many tourist destinations to diversify their positioning while standing out. Quebec is no exception to this craze for surfing, where local surfers appreciate the freedom and wide-open ...
Grégoire Moron-Garreau, Laurent Bourdeau   +1 more
doaj  

Health Monitoring of Invasive Pink Salmon Oncorhynchus gorbuscha in Norway in 2023

Aquaculture, Fish and Fisheries
Since 2019, the Norwegian Veterinary Institute (NVI) has conducted health monitoring of pink salmon in Norway. The primary purpose of health monitoring has been to examine the presence of selected notifiable infections in pink salmon, but also to gain ...
Åse Helen Garseth, Lisa Furnesvik, Kristoffer Vale Nielsen, Anne Berit Olsen, Julie Christine Svendsen, Torfinn Moldal   +5 more
doaj   +1 more source

PREVALENCE OF TRICHOMONIASIS IN DOMESTIC AND WILD PIGEONS AND ITS EFFECTS ON HEMATOLOGICAL PARAMETERS [PDF]

Pakistan Veterinary Journal, 2008
The present study was conducted to determine the prevalence of trichomoniasis and its effect on some blood parameters in pigeons. A total of 100 samples from the pigeons (50 wild and 50 domestic) were collected during the months of March and April 2005 ...
M. H. SALEEM, M. S. KHAN, A. S. CHAUDRY AND H. A. SAMAD
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Domestication of medicinal plants (Lonicera japonica Thunb.) in China: comparison of morphological, resistance and biochemical traits between wild and cultivated populations

Frontiers in Plant Science
BackgroundMost studies on domesticated plants have focused on those utilized for sustenance purposes. This study provides valuable insights into the domestication processes of honeysuckle (Lonicera japonica Thunb.), a semi-evergreen twining vine in the ...
Congzhe Hou, Luyao Huang, Zhuangzhuang Li, Nan Sun, Sheng Yang, Jia Li, Zhenhua Liu   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Utilizing Integrated UHPLC-Q-Exactive Orbitrap-MS, Multivariate Analysis, and Bioactive Evaluation to Distinguish between Wild and Cultivated Niudali (Millettia speciosa Champ.)

Molecules
Millettia speciosa Champ. (MSCP) enjoys widespread recognition for its culinary and medicinal attributes. Despite the extensive history of MSCP cultivation, the disparities in quality and bioactivity between wild and cultivated varieties have remained ...
Yuwei Zeng, Qing Yang, Binbin Huang, Ming Chen, Zichang Liang, Zhifeng Zhang, Jianguang Zhang   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source