Results 111 to 120 of about 2,948,697 (307)

Wild-type1 3D

, 2018
3D microCT reconstruction of mouse tibiae-wild ...
Anna Maria Ranzoni (4067443), Michelangelo Corcelli (4067437), Timothy Arnett (4067440), Pascale V. Guillot (139827)   +3 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Origem e distribuição das principais artérias do membro torácico de Cuniculus paca (Linnaeus, 1766)

Pesquisa Veterinária Brasileira
RESUMO: Objetivou-se descrever as artérias do membro torácico da paca (Cuniculos paca Linanaeus, 1766), mediante a dissecação da região. Para tanto, foram utilizadas 10 pacas adultas, machos ou fêmeas, pesando entre cinco e 10 kg do plantel de pacas do ...
Leonardo M. Leal, Saliha Samidi, Fabrício S. de Oliveira, Tais H.C. Sasahara, Bruno W. Minto, Márcia R.F. Machado   +5 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Genetic Diversity and Genetic Structure in Wild Pecan Germplasm: A Case Study in Argentina

Agrociencia Uruguay
For the last 20 years, Argentina has been proposed as an emerging market with great potential for pecan production, with an estimated annual production of around 3000 tons.
María Cristina Soldati, Noelia Oroño, María Florencia Pomponio, Enrique Alberto Frusso   +3 more
doaj   +1 more source

Emperor penguins, Queen Mary land, [Australasian Antarctic Expedition, 1911-1914] [picture] /

, 1911
Part of collection: Sir Douglas Mawson collection of Antarctic photographs.; Condition: Good.; Inscription: "Neg.Q.307 (Wild 39); Emperor penguins, Queen Mary land,"--In pencil on verso.; Also available in an electronic version via the Internet at: http:/
Wild, Frank, 1873-1939
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

[Man sitting by a kitchen stove, Australasian Antarctic Expedition, 1911-1914] [picture] /

, 1911
Part of collection: Sir Douglas Mawson collection of Antarctic photographs.; "Neg. Q. 2 64 (Wild 84)"--In pencil on verso.; Condition: Good; glued to backing board.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...
Wild, Frank, 1873-1939.
core  

Wild-type5 3D

, 2018
3D microCT reconstruction of mouse tibiae-wild ...
Anna Maria Ranzoni (4067443), Michelangelo Corcelli (4067437), Timothy Arnett (4067440), Pascale V. Guillot (139827)   +3 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source