Results 101 to 110 of about 6,828,704 (361)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genetic diversity of peanut (Arachis hypogaea L.) and its wild relatives based on the analysis of hypervariable regions of the genome [PDF]

, 2004
BACKGROUND: The genus Arachis is native to a region that includes Central Brazil and neighboring countries. Little is known about the genetic variability of the Brazilian cultivated peanut (Arachis hypogaea, genome AABB) germplasm collection at the DNA ...
Ferreira, Marcio Elias, Hopkins, Mark S, Kresovich, Stephen, Mitchell, Sharon E, Moretzsohn, Marcio de Carvalho, Valls, Jose Francisco Montenegro   +5 more
core   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hoverflies in organic apple orchards in north-western Italy [PDF]

, 2006
A list is given of hoverflies collected by means of Malaise and white sticky traps in two organic apple orchards in north-western Italy. The total number of collected species was 17 and it was compared with literature, in order to discuss differences due
Alberto, Alma, Gamba, Ursula, Pinna, Massimo, Rossi, Jacopo, Spagnolo, Sandra, Visentin, Cristina   +5 more
core  

Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination [PDF]

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern due to limited treatment options. The recent description of a mecA homologue, mecC in human and cattle, led to studies to detect this new variant in human and other animal ...
Concepcion Porrero, M., Diez-Guerrier, Alberto, Dominguez, Lucas, Domínguez Rodríguez, Lucas, Domínguez, Lucas, Díez-Guerrier, Alberto, Fernández-Garayzábal, José Francisco, Francisco Fernandez-Garayzabal, Jose, Harrison, Ewan, Harrison, Ewan M, Holmes, Mark A., Paterson, Gavin K., Porrero, M. Concepción   +12 more
core   +1 more source

Mobilization and Role of Starch, Protein, and Fat Reserves during Seed Germination of Six Wild Grassland Species

Frontiers in Plant Science, 2018
Since seed reserves can influence seed germination, the quantitative and qualitative differences in seed reserves may relate to the germination characteristics of species.
Ming Zhao, Hongxiang Zhang, Hong Yan, Lu Qiu, C. Baskin   +4 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Unprecedented variation pattern of plastid genomes and the potential role in adaptive evolution in Poales

BMC Biology
Background The plastid is the photosynthetic organelle in plant cell, and the plastid genomes (plastomes) are generally conserved in evolution. As one of the most economically and ecologically important order of angiosperms, Poales was previously ...
Hong Wu, De-Zhu Li, Peng-Fei Ma
doaj   +1 more source

Draft genome sequence of Colletotrichum acutatum sensu lato (Colletotrichum fioriniae) [PDF]

, 2014
In addition to its economic impact, Colletotrichum acutatum sensu lato is an interesting model for molecular investigations due to the diversity of host-determined specialization and reproductive lifestyles within the species complex.
Alahakoon, Cantarel, Damm, Dean, Freeman, Freeman, Guerber, Horton, Lardner, Lowe, Marcelino, O'Connell, Parra, Sreenivasaprasad, Zerbino   +14 more
core   +3 more sources

Cross-species transmission potential between wild pigs, livestock, poultry, wildlife, and humans: implications for disease risk management in North America

Scientific Reports, 2017
Cross-species disease transmission between wildlife, domestic animals and humans is an increasing threat to public and veterinary health. Wild pigs are increasingly a potential veterinary and public health threat. Here we investigate 84 pathogens and the
Ryan S. Miller, S. Sweeney, C. Slootmaker, Daniel A. Grear, Paul A. Di Salvo, Deborah Kiser, S. Shwiff   +6 more
semanticscholar   +1 more source