Results 121 to 130 of about 6,828,704 (361)

Microbial Evolution: Stalking the Wild Bacterial Species [PDF]

Current Biology, 2008
A recent report suggests that, when habitats are disturbed, bacterial populations that would be considered to be separate species can merge, reversing the process of speciation. But, for bacteria, 'species' remains undefined and undefinable.
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

A high-quality chromosome-level genome assembly of herbaceous bamboo species Lithachne pauciflora

Scientific Data
Lithachne pauciflora is a herbaceous bamboo species characterized by its short height, low degree of lignification, and dimorphic florets, making it a special model for studying the key trait evolution in bamboo.
Ke-Cheng Qian, Jun-Feng Liu, Yang Yang, Cen Guo, Zhen-Hua Guo   +4 more
doaj   +1 more source

Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant

eLife
Sex-biased genes offer insights into the evolution of sexual dimorphism. Sex-biased genes, especially those with male bias, show elevated evolutionary rates of protein sequences driven by positive selection and relaxed purifying selection in animals ...
Lei Zhao, Wei Zhou, Jun He, De-Zhu Li, Hong-Tao Li   +4 more
doaj   +1 more source

Draft genomes of two outcrossing wild rice, Oryza rufipogon and O. longistaminata, reveal genomic features associated with mating‐system evolution

Plant Direct, 2020
Oryza rufipogon and O. longistaminata are important wild relatives of cultivated rice, harboring a promising source of novel genes for rice breeding programs. Here, we present de novo assembled draft genomes and annotation of O.
Wei Li, Qun‐Jie Zhang, Ting Zhu, Yan Tong, Kui Li, Cong Shi, Yun Zhang, Yun‐Long Liu, Jian‐Jun Jiang, Yuan Liu, En‐Hua Xia, Hui Huang, Li‐Ping Zhang, Dan Zhang, Chao Shi, Wen‐Kai Jiang, You‐Jie Zhao, Shu‐Yan Mao, Jun‐ying Jiao, Ping‐Zhen Xu, Li‐Li Yang, Li‐Zhi Gao   +21 more
doaj   +1 more source

Multidrug-resistant Escherichia coli and Tetracycline-resistant Enterococcus faecalis in wild raptors of Alabama and Georgia, USA [PDF]

, 2019
Wild birds inhabit in a wide variety of environments and can travel great distances. Thus, wild birds can possibly spread antimicrobial resistance along the way, and this may represent a potential public health concern.
Bellah, Jamie, Butaye, Patrick, Hathcock, Terri, Kang, Yuan, Mobley, Tyler, Poudel, Anil, Raiford, Donna, Wang, Chengming   +7 more
core   +1 more source

Wild Chimpanzees Infected with 5PlasmodiumSpecies

Emerging Infectious Diseases, 2010
Data are missing on the diversity of Plasmodium spp. infecting apes that live in their natural habitat, with limited possibility of human-mosquito-ape exchange. We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni.
Kaiser, Marco, Löwa, Anna, Ulrich, Markus, Ellerbrok, Heinz, Goffe, Adeelia S., Blasse, Anja, Zommers, Zinta, Couacy-Hymann, Emmanuel, Babweteera, Fred, Zuberbühler, Klaus, Metzger, Sonja, Geidel, Sebastian, Boesch, Christophe, Gillespie, Thomas R., Leendertz, Fabian   +14 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular and Cytogenetic Characterization of Wild Musa Species

PLOS ONE, 2015
The production of bananas is threatened by rapid spreading of various diseases and adverse environmental conditions. The preservation and characterization of banana diversity is essential for the purposes of crop improvement. The world's largest banana germplasm collection maintained at the Bioversity International Transit Centre (ITC) in Belgium is ...
Cizkova, J., Hribova, E., Christelova, P., Van den houwe, Ines, Hakkinnen, M., Roux, N., Swennen, Rony, Dolezel, J.   +7 more
openaire   +8 more sources