Results 291 to 300 of about 6,828,704 (361)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

A Dreadful Loop: Can Reverse Zoonosis of COVID-19 Seed Unrestrained Spread and Mutations in Wild Species and Transmission of Novel Strains to Humans?

, 2020
He S, Han J.
europepmc   +1 more source

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A Wealth of Wild Species

, 2019
N. Myers
semanticscholar   +2 more sources

Genome size in wild Pisum species

Theoretical and Applied Genetics, 1996
Genome size was measured in 75 samples of the wild pea species Pisum abyssinicum, P. elatius, P. fulvum and P. humile by ethidium-bromide (EB) flow cytometry (internal standard: Triticum monococcum) and Feulgen densitometry (internal standard: Pisum sativum 'Kleine Rheinländerin').
M, Baranyi, J, Greilhuber, W K, Swięcicki   +2 more
openaire   +2 more sources

Geographic distribution of wild potato species

American Journal of Botany, 2001
The geographic distribution of wild potatoes (Solanaceae sect. Petota) was analyzed using a database of 6073 georeferenced observations. Wild potatoes occur in 16 countries, but 88% of the observations are from Argentina, Bolivia, Mexico, and Peru. Most species are rare and narrowly endemic: for 77 species the largest distance between two observations ...
Hijmans, R.J., Spooner, D.M.
openaire   +2 more sources

Cocaine distribution in wild Erythroxylum species

Journal of Ethnopharmacology, 2006
Cocaine distribution was studied in leaves of wild Erythroxylum species originating from Bolivia, Brazil, Ecuador, Paraguay, Peru, Mexico, USA, Venezuela and Mauritius. Among 51 species, 28 had never been phytochemically investigated before. Cocaine was efficiently and rapidly extracted with methanol, using focused microwaves at atmospheric pressure ...
Bieri, Stefan, Brachet, Anne, Veuthey, Jean-Luc, Christen, Philippe   +3 more
openaire   +3 more sources

Natural Antioxidants, Health Effects and Bioactive Properties of Wild Allium Species.

Current pharmaceutical design, 2020
BACKGROUND There is increasing interest from the pharmaceutical and food industry in natural antioxidant and bioactive compounds derived from plants as substitutes for synthetic compounds. The genus Allium is one of the largest genera, with more than 900
S. Petropoulos, Francesco Di Gioia, Nikos Polyzos, N. Tzortzakis   +3 more
semanticscholar   +1 more source

Discovery of Wild Triticum Species

2020
As mentioned above, as early as in 1833, Link found a wild plant similar to T. monococcum in the Balkans and Asia Minor. He named it as Crithodium aegilopoides Link. In 1854, Balansa found the same wild wheat in Mt. Sipylus, Syria, Iraq, and Iran in Asia Minor. They were merged into Triticum and changed to T. aegilopoides (Link) Bal. E. Boissier (1853)
Chi Yen, Junliang Yang, Zhongwei Yuan, Shunzong Ning, Dengcai Liu   +4 more
openaire   +1 more source