Results 91 to 100 of about 262,063 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Linking wilderness mapping and ecosystem services: Identifying integrated wilderness and ecological indicators to quantify ecosystem services of wilderness

Ecological Indicators
Wilderness has proven to provide a wide range of ecosystem services (ES). Wilderness have been shown to play an important role in preserving biodiversity and providing ES, which is indispensable to both nature and people.
Ruirui Zhu, Weiyi Liu, Ruixin Xue, Shuo Teng, Yefan Wang, Yanting Pan, Weijun Gao   +6 more
doaj   +1 more source

Proposed Release of Wilderness Study Areas in Montana (USA) Would Demote the Conservation Status of Nationally-Valuable Wildlands

Land, 2018
Wildlands are increasingly lost to human development. Conservation scientists repeatedly call for protecting the remaining wildlands and expanding the land area protected in reserves.
R. Travis Belote
doaj   +1 more source

The voice in the wilderness [PDF]

, 2008
Historical series, 16. Sermon preached on the second Sunday at the Christ Lutheran Church, Vancouver, British Columbia, Advent 2003.
Aadland, Marlin
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Borderless Boundaries – as Means of Death and Life: Wilderness Portraits in Patristic and Rabbinic Literature [PDF]

, 2015
This study examines the role played by environmental representation of an apparent borderless boundary, the desert, as presented in Scripture – the Hebrew Bible / First Testament.
Maoz, Daniel
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Aeolianite and barrier dune construction spanning the last two glacial-interglacial cycles from the southern Cape coast, South Africa [PDF]

, 2004
The southern Cape region of South Africa has extensive coastal aeolianites and barrier dunes. Whilst previously reported, limited knowledge of their age has precluded an understanding of their relationship with the climatic and sea-level fluctuations ...
Aharon, Andrew S Carr, Avery, Bard, Barrable, Barwis, Bascomb, Bateman, Bateman, Benjamin P Horton, Birch, Brooke, Chappell, Chappell, Cohen, Cowling, Davies, Deacon, Deacon, Dingle, Dingle, Dingle, Folk, Frechen, Henshilwood, Henshilwood, Illenberger, Illenberger, Illenberger, Irving, Kocurek, Lambeck, Lambeck, Malan, Malan, Manoj K Jaiswal, Mark D Bateman, Martin, Martin, Meadows, Murray, Peter J Holmes, Pirazolli, Potgieter, Prescott, Ramsay, Ramsay, Roberts, Shaw, Siesser, Siesser, Tankard, Thomas, Thomas, Van Andel, Vogel, Yokoyama, Zhou   +57 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Feasibility [PDF]

Extensive livestock farming, including hay making, seems the most feasible management strategy for open peatland. In the longer term, wilderness grazing may become more feasible. The loss of economic viability of traditional livestock farming and related
Bokdam, J., Braeckel, A., van
core   +1 more source