Results 111 to 120 of about 34,166 (314)

Episode 12 : Wilderness Childhood : an interview with Allan Renshaw

, 2011
Interviewee: Allan Renshaw | Interviewer: Debbie Lee and Jane Holman | Date: March 22, 2011 | Location: Cambridge, Idaho | In this episode, titled Wilderness Childhood, Allan Renshaw tells us what it was like to spend his young childhood in the ...
Debbie Lee; Jane Holman; Allan Renshaw;
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Wilderness networks contributed the efforts of existing protected area networks: The cost-effective comparison among multiple conservation scenarios

Global Ecology and Conservation
Biodiversity loss is a pressing global issue, with protected areas and Other Effective Area-Based Conservation Measures (OECMs) identified as crucial strategies for conservation.
Faxiang Hu, Kunyuan Wanghe, Xinle Guo, Shahid Ahmad, Aihua Fu, Menghan Deng, Shiwei Lin, Xiaofeng Luan   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rock Island Bend, Franklin River, South West Tasmania [picture] /

, 1983
On foot border: Australia's wilderness : world heritage area.; S11121.Rock Island Bend, Franklin River, South West ...
Dombrovskis, Peter, 1945-1996.
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Building an inclusive conservation vision founded upon ecological values and social opportunities

Environmental Research: Ecology
We developed a spatially explicit model for the eastern United States to help identify where we work to conserve a network of ecologically important lands with the input of communities often excluded from conservation planning.
Peter S McKinley, Lia Cheek, R Travis Belote   +2 more
doaj   +1 more source

Wilderness beyond the natural: Mapping urban novel wilderness to support ecological conservation and recreational provision in rapidly urbanizing areas

Ecological Indicators
With urbanization accelerating, preserving and utilizing urban wilderness is crucial for sustainable development. This study focuses on Shenzhen, China, developing a framework to identify and manage urban novel wilderness areas. Using the Weighted Linear
Lei Shen, Duanqiang Zhai, Chang Li
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Episode 17 : What is the Greatest Threat to Wilderness : a special collective interview

, 2012
Interviewee : Ed Boedel, Penny Keck, Bruce Farling, Eric Melson, Rob Mason, Warren Miller | Interviewer : Debbie Lee | Date : May 14, 2012 | This is a special episode, titled What is the Greatest Threat to Wilderness? Debbie Lee, our project ...
Debbie Lee; Ed Bloedel; Penny Keck; Bruce Farling; Eric Melson; Rob Mason; Warren Miller;
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source