Results 121 to 130 of about 34,166 (314)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2012 The interest for this thesis stemmed from existing critical discussions of the difference between the landscapes demarcated by the words “wilderness” and “wildness.” For example, in Walden, Henry David Thoreau pointedly uses the word “wild,” rather than “
Ceronie, Katelin
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Wilderness protection in the Czech Republic
, 2019 Introduction As in many European countries there has been considerable debate in the Czech Republic throughout the past decade over wilderness sensu lato and non-intervention management in protected areas. Critics may describe this as following a fashion,
Křenová, Zdeňka, Zicha, Jiří
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Utah Wilderness News, May 1986
, 1986 A publication of the Utah Wilderness Coalition published in May 1986. Summary of wilderness in Zion-Hot Desert, Cedar Mesa, and Canyonlands regions of Utah, giving a synopsis of each area's status, the relationship to nearby wilderness lands such as ...
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
AN ANALYSIS OF WILLINGNESS TO PARTICIPATE IN WILDERNESS OR OTHER PRIMITIVE AREAS
A logit model was used to determine the major factors explaining willingness to participate of an individual in the wilderness or other primitive area visits.
Bergstrom, John C. +5 more
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Wilderness Values and Archaeological Resource Management.
, 2016 Most archaeological sites in wilderness have value primarily for the information they can yield. Often, information value can be realized only through methods such as excavation and artifact collection that physically consume part of the site and remove ...
Lipe, William
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source